ID A0A2Y9JME4_ENHLU Unreviewed; 832 AA.
AC A0A2Y9JME4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=LOC111149466 {ECO:0000313|RefSeq:XP_022362263.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022362263.1};
RN [1] {ECO:0000313|RefSeq:XP_022362263.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022362263.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022362263.1; XM_022506555.1.
DR AlphaFoldDB; A0A2Y9JME4; -.
DR STRING; 391180.A0A2Y9JME4; -.
DR KEGG; elk:111149466; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF37; ANOCTAMIN-9; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 267..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 347..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 453..472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 503..525
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 623..653
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 673..697
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 259..815
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 832 AA; 95506 MW; 02F0B62A046C14A2 CRC64;
MRSETNQSEK DDDRLTSLGL ATAFYLALGP PHTPGPDTPT WAWAASFAVA TVQCTCSKCP
LGQFLTPPRG PGAVLQDLSS PPELGEERLR ILTGTEGDSF LLVEIRPGET EAPERWDYVL
VADRCTQRNA EQVRRQQHFL EELERKGFHY KMIEDREKVY FGIRADGRIF DLYHTLLMDP
EGPAARVQPT RPTPVPATTR IRIVNFVLNS KTAAGDTLED LLKSGVFETR FALHKGEEGL
KKNWAQWRNM VRCQPIDDIR DYFGEKVALY FAWLGWYTYM LVPAAVVGLI VFLSGFSLFN
ASQISKEICE AHDVLLCPRG DHSRRYQQLS DTCTFAKLTH LFDNEGTVVF AIFMALWATV
FLEIWKRQRA RVVLHWDLYG WDEDQEEMAL EFINCPDYEL RPHQHSYLRS SVILVLSLFM
ICLMIGMAHL LVVYRVLAAA LFNSALLFQE EQVTTAVVVT GALVHYVVIL IMTKINKYVA
LKLCDFEQPR TFSERESKFT IKFFTLQFFA HFSSLVYIAF ILGRINGHPG KSVRLAGLWK
LEECHLSGCM MDLFLQMAII MGLKQTLSNC VEYLSPWLAH KWRLMRFRLG RASGEPKLRD
LWHNYLLNPV GTFSLFDEFM EMMIQYGFTT IFVAAFPLAP LLALFSNLVE IRLDAIKMVR
LQRRLVPRKA KDIGTWLQVL ETIGVLAVIA NGMVIAFTSE FIPRVVYKYH YGPCRTGAQP
TVDCLTGYVN HSLSVFYTKD FQDPIQTEGS ENVTQCRYRD YRNAPDYSLS EQFWVLLAIR
LVFLILFEHV ALCIKLIAAW FVPDVPQSVK NKVLEEKYQM LREKMRSRST EV
//
