ID A0A2Y9JMF4_ENHLU Unreviewed; 1302 AA.
AC A0A2Y9JMF4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 3 isoform X1 {ECO:0000313|RefSeq:XP_022362137.1};
GN Name=LOC111149403 {ECO:0000313|RefSeq:XP_022362137.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022362137.1};
RN [1] {ECO:0000313|RefSeq:XP_022362137.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022362137.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_022362137.1; XM_022506429.1.
DR STRING; 391180.A0A2Y9JMF4; -.
DR KEGG; elk:111149403; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 11.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF43; LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 4; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 10.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 14.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..1302
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015969326"
FT DOMAIN 108..140
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 276..319
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 354..394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 402..454
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 573..614
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 615..652
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 659..701
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 743..783
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 784..824
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 825..864
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 865..907
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 916..970
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1035..1075
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1081..1121
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1135..1185
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT REGION 245..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1187..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..271
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 112..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 130..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1302 AA; 138949 MW; 27F967CAC54D384E CRC64;
MPGPRGAAGG LAPEMRGAGA AGLLALLLLL LLPLGPGGGA EGGPAGERGA GGGGALARER
FKVVFAPVIC KRTCLKGQCR DSCQQGSNMT LIGENGHSTD TLTGSGFRVV VCPLPCMNGG
QCSSRNQCLC PPDFTGRFCQ VPAGGAGGGT GGSGPGLGRA GTLSTGALPP LAPESESVAS
KHAIYAVQVI ADPPGPGEGP PAQHAAFLVP LGPGQISAEV QAPPPVVNVR VHHPPEASVQ
VHRIEGPNAE GPAPSQHLLP HPKPQHPRPP TQKPLGRCFQ DTLPKQPCGS NPLPGLTKQE
DCCGSIGTAW GQSKCHKCPQ LQYTGVQKPG PLRGEVGADC PLGYKRLNST HCQDINECAM
PGMCRHGDCL NNPGSYRCVC PPGHSLGPSR TQCIADKPEE KSLCFRLVSP EHQCQHPLAT
RLTRQLCCCS VGKAWGARCQ RCPADGTAAF KEICPAGKGY HILTSHQTLT IQGESDFSLF
LHPDGPPKPQ QLPESPSRAP PPEDTEEERG VSTDSPVVEE QSAAQSHPTA TTSPARPYPE
LISRPSPPTV RWFLPDLPPS RSAVEIAPTQ VTETDECRLN QNICGHGECV PGPSDYSCHC
NPGYRSHPQH RYCVDVNECE AEPCGAGRGV CMNTGGSYNC HCNRGYRLHV GAGGRSCVDL
NECAKPHLCG DGGFCLNFPG HYKCNCYPGY RLKASRPPVC EDIDECRDPS SCPDSKCENK
PGSFKCIACQ PGYRSQGGGA CRDVNECAEG SPCSPGWCEN LPGSFRCTCA QGYAPAPDGR
SCQDVDECEA EDVCDNGICT NTPGSFQCQC LSGYHLSRDR SRCEDIDECD FPAACIGGDC
INTNGSYRCL CPQGHRLVGG RKCQDIDECS QDPGLCLPHG ACENLQGSYA CICDEGFTPT
QDHHGCEEVE PPHHKKECYL NFDDTVFCDS VLATNVTQQE CCCSLGAGWG DHCEIYPCPV
YSSAEFHSLC PDGKGYTQDN NIVNYGIPAH RDIDECILFG AEICKEGKCV NTQPGYECYC
KQGFYYDGNL LECVDVDECL DESNCRNGVC ENTRGGYRCA CTPPAEYSPA QRQCLSPEEM
DVDECQDPAA CRPGRCVNLP GSYRCECRPP WVPGPSGRDC QLPESPAERA PELRDVCWAQ
RGEDGMCAGP LAGPTLTFDD CCCRQGRGWG AQCRPCPPRS SGSQCPTSQS ESNSFWDASP
LLLGKPPREE DSSEEDSDEC RCVSGRCVPR PGGAVCECPG GFQLDASRAR CVDIDECREL
NQRGLLCKSE RCVNTSGSFR CVCKAGFARS RPHGACVPQR RR
//
