ID A0A2Y9JMN8_ENHLU Unreviewed; 1019 AA.
AC A0A2Y9JMN8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=P53-induced death domain-containing protein 1 isoform X1 {ECO:0000313|RefSeq:XP_022362358.1};
GN Name=LOC111149557 {ECO:0000313|RefSeq:XP_022362358.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022362358.1};
RN [1] {ECO:0000313|RefSeq:XP_022362358.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022362358.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022362358.1; XM_022506650.1.
DR AlphaFoldDB; A0A2Y9JMN8; -.
DR STRING; 391180.A0A2Y9JMN8; -.
DR KEGG; elk:111149557; -.
DR OrthoDB; 894110at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08779; Death_PIDD; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR019502; Peptidase_S68_pidd.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF42; LEUCINE RICH REPEATS AND DEATH DOMAIN CONTAINING 1; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF10461; Peptidase_S68; 1.
DR Pfam; PF00791; ZU5; 2.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 401..561
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 562..703
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 897..982
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 471..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 551
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 553
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 693
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 695
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT SITE 552..553
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
FT SITE 694..695
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
SQ SEQUENCE 1019 AA; 111336 MW; 60C966AAAA4B4291 CRC64;
MAAEEEWLEP EAAAPEDAAG EVVDAVDGEP GDPHLLLGNR LNLHLYPRGC HRLLHLCAQR
APQLLEVEFL QLSGHEDPRL LEATLAQVPA NLQHLRSLVL RGGQQQDVLG ACSRGFLTTL
PAGLSDLARL AHLDLSFNSL ETLPACVPQM RGLSTLLLSY NCLSELPDSL GAFPSLSFLS
VSHNCLRTLP PALGSLSALQ RLDLSENLLD TLPPEIGDLS SLTELNLASN QLQGLPISLG
KSESCSSGSL GLTGSALQPL PGSTLVLHGG PCTHWLGPPW SLQSSLVALV CRPSLARAGS
GPEGPLPTLS CPLPPVGLRS LRFLILHSNL LTSVPSGLAH LPLLARLDLR DNQLRDVPPE
LLDAPFVRLQ GNPLGKALPA SHSAPETPVT REMPRLFLNS DLDSFLVTPQ GCLVTLACGV
RLRFPAGATA DPINIHYRLR LPEPRLVPLG PHDALLSAVL ELRPHGVAFQ QARPGHSGRG
AEQAGPGMGP SAHTSPAWQE VGLWLLFVPP RARRCREVVV RTLSDDSWSD LETHLEEEAP
KRLWAHCQVP HFSWFLVVSR PVSNTCLVPP EGTLLCSSGH PGVKVTFPPG ATDEPRRVRM
QVVHMAGREL RALLEEPGAA ASPLLCLSQR GTSSFLQPVT VQLPLPPGVT GLSLDRTCLH
LLYWAPPAAA WDDITAQVVL EITHLYARFR VTHFSWYWLW HTTKSCVQGL ARKAWERLRL
HQVNLIALQR RRDPEQVLLQ CLPRRKVDAT LQRLLDRYRG PEPSDTVEMF EGEKFFAAFE
KGIDVDADRP DCVEGRIYFV FYSHLKNLKE VYVTTALDRR AQAVRGQVSF YRGAVSEEVP
EEAAAARQRK GADPLWMATL PIKLPRLRGS QGPGQGQGAS LSLAPLNLGD AETGFLTQSN
LLNVAGRLGT DWPAVALHLG MPYRELQRIR HEFRDDLDGQ IRCMLFSWAE RQAGQPGAVG
LLVRALEQSD RLDIAEEVRA ILELGRQKYK DSIQRASLAP RDLAPPEPSA SQSPESAQA
//
