ID   A0A2Y9JNA9_ENHLU        Unreviewed;       748 AA.
AC   A0A2Y9JNA9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Heterogeneous nuclear ribonucleoprotein U-like protein 2 {ECO:0000313|RefSeq:XP_022362578.1};
GN   Name=LOC111149663 {ECO:0000313|RefSeq:XP_022362578.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022362578.1};
RN   [1] {ECO:0000313|RefSeq:XP_022362578.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022362578.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_022362578.1; XM_022506870.1.
DR   AlphaFoldDB; A0A2Y9JNA9; -.
DR   STRING; 391180.A0A2Y9JNA9; -.
DR   KEGG; elk:111149663; -.
DR   OrthoDB; 5402316at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR   CDD; cd12884; SPRY_hnRNP; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.720.30; SAP domain; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003034; SAP_dom.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035778; SPRY_hnRNP_U.
DR   PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR   PANTHER; PTHR12381:SF66; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U-LIKE PROTEIN 2; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF02037; SAP; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00513; SAP; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF68906; SAP domain; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50800; SAP; 1.
PE   4: Predicted;
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Ribonucleoprotein {ECO:0000313|RefSeq:XP_022362578.1}.
FT   DOMAIN          3..37
FT                   /note="SAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50800"
FT   DOMAIN          227..420
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          40..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..98
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..642
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  85019 MW;  9D79F8A3E65F17B4 CRC64;
     MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG AGPGGACKAE
     PRPVAASGGG PGGDEEDDEE EEEEDEEALL EDEDEEPPPA LVSGQAAQPP PEPPEAAAME
     AAAEPDASEK PAEESTAGSG GVNGGEEQGT GKGEEDEPEE RSGDETPGSE APGDKAAEEQ
     GDDQDSEKSK PAGSDGERRG VKRQRDEKDE HGRAYYEFRE EAYHSRSKSP PPPEEEAKDE
     EEDQTLVNLD TYTSDLHFQV SKDRYGGQPL FSEKFPTLWS GARSTYGVTK GKVCFEAKVT
     QNLPMKEGCT EVSLLRVGWS VDFSHPQLGE DEFSYGFDGR GLKAENGQFE EFGQTFGEND
     VIGCFANFEA EEVELSFSKN GEDLGVAFRI NKESLAERAL LPHVLCKNCV VELNFGQKEE
     PFFPPPEEFV FIHAVPVEER VRTAVPPKTI EECEVILMVG LPGSGKTQWA LKYAKENPEK
     RYNVLGAETV LNQMRMKGLE EPEMDPKSRD VLVQQASQCL SKLVQIASRT KRNFILDQCN
     VYNSGQRRKL LLFKTFSRKV VVVVPNEEDW KKRLELRKEV EGDDVPESIM LEMKANFSLP
     EKCDYMDEVT YGELEKEEAQ PIVTKYKEEA RKLLPPSEKR TNRRNNRNKR NRQNRSRGQG
     YVGGQRRGYD NRAYGQQYWG QSGNRGGYRN FYDRYRGDYD RFYGRDYEYN RYRDYYRQYS
     RDWQNYYYHH PQDRDRYYRN YYGYQGYR
//