ID   A0A2Y9JPA1_ENHLU        Unreviewed;      1220 AA.
AC   A0A2Y9JPA1;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 5 {ECO:0000313|RefSeq:XP_022362933.1};
GN   Name=LOC111149954 {ECO:0000313|RefSeq:XP_022362933.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022362933.1};
RN   [1] {ECO:0000313|RefSeq:XP_022362933.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022362933.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_022362933.1; XM_022507225.1.
DR   STRING; 391180.A0A2Y9JPA1; -.
DR   KEGG; elk:111149954; -.
DR   OrthoDB; 201873at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_022362933.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT   TRANSMEM        717..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        801..822
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        865..886
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        941..961
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..268
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          734..977
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          682..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1104..1141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1104..1128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1220 AA;  136302 MW;  5AAF5143D9287117 CRC64;
     MPEAGGSCPW GPRMVASGSG PGLCRGEIEF GGSGKKRGKF VKVPSDVAPS ELFNLLLAEW
     HLPAPNLVVS LVGEERPFAM KPWLRDVLRK GLVKAAQSTG AWILTSALRV GLARYVGQAV
     RDHSLASTST RARVVAIGFA SLGRVLHRQL LDNAQEHSPV HYPADEGSGG GPLCSLDNNQ
     AHFILVEPGP CGTGDELAEL RLKLEKHISE QRTGYGGTGS IEIPVLCLLV NGDPSTLERI
     SRAVEHAAPW LVLAGSGGIA DVLAALMNQP HLLVPQVAEK QFKEKFPGEH FCWEDIVHWT
     ELLQNITSHP HLLTVHDFEQ EGTEELDTVI LKALVKACKS HSQEAQDYLD ELKLAVAWDR
     VDIARSEIFN GDVEWKSCDL EEVMMDALVS DKPEFVRLFV DNGADVGDFL TYGRLQQLYR
     STPPKSLLFD LLQRKHEEGR LTLAGLGAQQ AREPPTGLPA FSLHEVSRLL KDFLHDACRG
     LYQEERGPAR RPEGRKWLLD LNRKSENPWR DLFLWAVLQN RHEMATYFWA MGQEGVAAAL
     AACKILREMS HLETGAGVRR PVREAKYEQL ALGLFSECYG NSEDRAFALL VRRNRGWSRA
     TCLHLATEAD TKAFFAHDGV QAFLTKIWWG DMASGTPILR LLCAFLCPAL IYTNFITFSE
     EAPLRSGPEG LQELDSLDTE KSLLCSPGSR PEELAETPRA QGGPGPRAAF LLTRWRMFWG
     APVTVFLGNV VMYFAFLFLF AYVLLVDFRP PPQGPSGPEV TLYFWVFTLV LEEIRQGFFS
     DEDTHLVKKF TLYVEDNWNK CDMVAIFLFI AGVTCRMVPS MFEAGRTVLA VDFMVFTLRL
     IHIFAVHKQL GPKIIIVERM MKDVFFFLFF LSVWLVAYGV TTQALLHPHD GRLEWVFRRV
     FYRPYLQIFG QIPLDEIDEA RVNCSLHPLL EEGSPSCPNL YANWLVILLL VTFLLVTNVL
     LMNLLIAMFS YTFQVVQGNA DTFWKFQRYH LIVEYHQRPA LAPPFIVLSH LSLLLKRLLR
     KGAAQKRAHL GRDLPEPLDQ KMVTWEAVQK ENYLGKLEKQ RKGSKEEVLR KTAHRVDSVA
     QHLGGLREQE RRIKRLESQV SSWASRSSXW GPPPSSLHPS TQAGQGTARG GTVPVPASIG
     DFGDNVPSLE GILSFRPPHC PLCTPEPCPH ACSHSYGRGG PWGGRAHGLP QTPLSPPGRL
     LHGAPVLHSP AQRQLELPDL
//