ID A0A2Y9JRL4_ENHLU Unreviewed; 2743 AA.
AC A0A2Y9JRL4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Adenomatous polyposis coli protein isoform X9 {ECO:0000313|RefSeq:XP_022360455.1};
GN Name=LOC111148270 {ECO:0000313|RefSeq:XP_022360455.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022360455.1};
RN [1] {ECO:0000313|RefSeq:XP_022360455.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022360455.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR RefSeq; XP_022360455.1; XM_022504747.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05972; APC_15aa; 4.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF16634; APC_u13; 1.
DR Pfam; PF16635; APC_u14; 1.
DR Pfam; PF16636; APC_u15; 1.
DR Pfam; PF16630; APC_u5; 1.
DR Pfam; PF16633; APC_u9; 1.
DR Pfam; PF00514; Arm; 3.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF58050; N-terminal coiled coil domain from apc; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 4..55
FT /note="Adenomatous polyposis coli N-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16689"
FT REPEAT 559..601
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2124..2475
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT DOMAIN 2570..2743
FT /note="EB-1 binding"
FT /evidence="ECO:0000259|Pfam:PF05937"
FT REGION 239..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1302..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1776..1843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1866..1911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1943..1971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2048..2538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2565..2614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2632..2743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 6..54
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 134..168
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 244..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1062
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1443..1461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1686..1731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1776..1794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1795..1837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2070..2091
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2100..2125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2134..2149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2158..2326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2361..2407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2419..2433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2457..2480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2481..2496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2517..2538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2569..2586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2597..2611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2637..2713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2723..2743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2743 AA; 300823 MW; 3FFFA00D55CF8C51 CRC64;
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM
ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC SPVPMGSFPR
RGFVNGSREN TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL
QTDMTRRQLE YEARQIRVAM EEQLGTCQDM EKRAQRRVTR IQQIEKDILR IRQLLQSQAT
EAERSSQNKH EAGSHEAERQ NEGQGVAEIN MATSGSGQGS TTRMDHETAS VLSSSSTHSA
PRRLTSHLGT KIRAYCETCW EWQEAHEQGM DQDKNPMPAP VEHQICPAVC VLMKLSFDEE
HRHAMNELGG LQAIAELLQV DCEMYGLTND HYSITLRRYA GMALTNLTFG DVANKATLCS
MKGCMRALVA QLKSESEDLQ QVIASVLRNL SWRADVNSKK TLREVGSVKA LMECALEVKK
ESTLKSVLSA LWNLSAHCTE NKADICAVDG ALAFLVGTLT YRSQANTLAI IESGGGILRN
VSSLIATNED HRQILRENNC LQTLLQHLKS HSLTIVSNAC GTLWNLSARN PKDQEALWDM
GAVSMLKNLI HSKHKMIAMG SAAALRNLMA NRPAKYKDAN IMSPGSSLPS LHVRKQKALE
AELDAQHLSE TFDNIDNLSP KASHRNKQRH KQSLYNDYVF DTNRHDDNRS DNFNTGNMTV
LSPYLNTTVL PSSSSSRGSL DSSRSEKDRS LERERGISLG NYHPATENSG TSSKRGLQIS
TTAAQIAKVM EEVSAIHTSQ EDRSSGSTTE LHCGTDERNA LRRSSTAHTH ANTYNFSKSE
GSNRTCPVTY ANLEYKRSSN DSLNSVSSSD GYGKRGQMKP SIESYSEDDE SKFCSYGQYP
ADLAHKIHSA NHMDDNDGEL DTPINYSLKY SDEQLNSGRQ SPSQNERWAR PKHIIEDEIK
QSEQRQSRSQ STTYPVYTES TDDKHLKFQP HFGQQECVSP YRSRGASGSE TNRVGSNHGI
NQNVNQSLCQ EDDYEDDKPT NYSERYSEGE QHEEEERPTN YSIKYNEEKH HVDQPIDYSL
KYATDISSSQ KPPFSFSKNS SGQSTKTEHL SSSSENTSTP SANAKRQNQH HPSSAQSRNG
QTPKATSCKV PSINQETIQT YCVEDTPICF SRCSSLSSLS SAEDEIGCDQ ATQETDSANT
LQIAEIKENS GTRTTEDSVS EVPTVSQHIR TKSSRLQASG LSAESTRHKA VEFSSGAKSP
SKSGAQTPKS PPEHYVQETP LMFSRCTSVS SLDSFESRSI ASSVQSEPCS GMVSGIISPS
DLPDSPGQTM PPSRSKTPPP PPQTVQTKRE VPKNKAPAVE KRESGPKQAA VNAAVQRVQV
LPDADTLLHF ATESTPDGFS CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ
PEEANENQEK ETEKPTDSEK DLLDDSDDDD IEILEECIIS AMPTKSSRKA KKPAQTASKL
PPPVARKPSQ LPVYKLLPSQ NRLQAQKHVS FTPGDDMPRV YCVEGTPINF STATSLSDLT
IESPPNELAA GEGVRPGAQS SEFEKRDTIP TEGRSTDEAQ RGKTPSVTIP ELDDSKTEEG
DILAECINSA MPKGKSHKPF RVKKIMDQVQ QASMSSSGAN KNQLDGKKKK PTSPVKPIPQ
NTEYRTRVRK NADSKNNLNA ERTFSDNKDS KKQNLKNNSK DFNDKLPNNE DRVRGSFTFD
SPHHYTPIEG TPYCFSRNDS LSSLDFDDDD VDLSREKAEL RKGKENKESE AKVTSHTELT
TNQQSANKTQ AVTKHPINRG QSKSLLQKQS TFPQSSKDIP DRGAATDEKL QNFAIENTPV
CFSRNSSLSS LSDIDQENNN NKENEPIKET EPPNSQGEPS KPQASGYAPK SFHVEDTPVC
FSRNSSLSSL SIDSEDDLLQ ECISSAMPKK KKPSRLKGDN EKHSPRNMSG ILAEDLTLDL
KDIQRPDSEH GLSPDSENFD WKAIQEGANS IVSSLHQAAA AACLSRQASS DSDSILSLKS
GISLGSPFHL TPDQEEKPFT SNKGPRILKP GEKSTLETKK IESENKGIKG GKKVYRSLLT
GKVRSNSEIS NQMKQSLQAN MPSISRGRTM IHIPGVRNSS SSTSPVSKKG PPLKTPASKS
PSEGQTATTS PRGPKPSVKS ELSPVTRQTS QPAVANKGPS RSGSRDSTPS RPAQQPLSRP
MQSPGRNSIS PGRNGISPPN KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQMSQQNLTK
QTGLSKNGSS IPRSESASKG LNQMNNSNGS NKKVELSRMS STKSSGSESD RSERPVLVRQ
STFIKEAPSP TLRRKLEESA SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHSSVQ
SGGWRKLPPN LSPTIEYNDG RPVKRHDIAR SHSESPSRLP INRSGTWKRE HSKHSSSLPR
VSTWRRTGSS SSILSASSES SEKAKSEDEK HVNSISGAKQ TKENQVSTKG TWRKIKESEI
SPTNSTSQTT SSGAANGAES KTLIYQMAPA VSKTEDVWVR IEDCPINNPR SGRSPTGNTP
PVIDTVSEKG NPNAKDAKDN QGKQNVGNGS APVRTMGLEN RLNSFIQVDA PDQKGTEAKP
GQSNPVPASE TNESSVAERT PFSSSSSSKH SSPSGTVAAR VTPFNYNPSP RKSSADSTSA
RPSQIPTPVN NNTKKRDSKT DSTESSGTQS PKRHSGSYLV TSV
//
