ID A0A2Y9JRM6_ENHLU Unreviewed; 432 AA.
AC A0A2Y9JRM6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Forkhead box protein P3 isoform X1 {ECO:0000313|RefSeq:XP_022363673.1};
GN Name=LOC111150492 {ECO:0000313|RefSeq:XP_022363673.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022363673.1};
RN [1] {ECO:0000313|RefSeq:XP_022363673.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022363673.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_022363673.1; XM_022507965.1.
DR AlphaFoldDB; A0A2Y9JRM6; -.
DR STRING; 391180.A0A2Y9JRM6; -.
DR KEGG; elk:111150492; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20066; FH_FOXP3; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047413; FH_FOXP3.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF5; FORKHEAD BOX PROTEIN P3; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 338..424
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 338..424
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 47435 MW; BB8BF45724742D64 CRC64;
MPNPRPAKPS APSLVLGPSP GASPNWRATP KASDLLGAKG PGATFQGRDL RGGAHASSSS
SLNPMPPSQL QLPTVPLVMV APSGARLGPS PHLQALLQDR PHFMHQLSTV DTHTRTPVLQ
VRPLDSPAMI SLPPPTAATS VFSLKARPGL PPGINVASLE WVSREPALLC TFPSPSTPRK
DSALSTVPQG SYSLLANGVC KWPGCEKVFE EPEDFFKHCQ ADHLLDEKGR AQCLLQREVV
QSLEQQLVLE KEKLGAMQAH LAGKMALTKA PSTVSSDKGS CCIVASGTPV TTGPAWPSPQ
EAPDGLFAVR RHLWGSHGNS TFPEFFHNMD YFKFHNMRPP FTYATLIRWA ILEAPEKQRT
LNEIYHWFTR MFAFFRNHPA TWKNAIRHNL SLHKCFVRVE SEKGAVWTVD EFEFRKKRSQ
RPSRSANPTP GP
//
