ID A0A2Y9JRR1_ENHLU Unreviewed; 687 AA.
AC A0A2Y9JRR1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Sex comb on midleg-like protein 2 {ECO:0000313|RefSeq:XP_022363708.1};
GN Name=LOC111150512 {ECO:0000313|RefSeq:XP_022363708.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022363708.1};
RN [1] {ECO:0000313|RefSeq:XP_022363708.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022363708.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
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DR RefSeq; XP_022363708.1; XM_022508000.1.
DR AlphaFoldDB; A0A2Y9JRR1; -.
DR STRING; 391180.A0A2Y9JRR1; -.
DR KEGG; elk:111150512; -.
DR OrthoDB; 2908161at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20109; MBT_SCML2_rpt2; 1.
DR CDD; cd09578; SAM_Scm; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR047531; SAM_Scm-like.
DR InterPro; IPR033763; SCML2_RBR.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF84; SEX COMB ON MIDLEG-LIKE PROTEIN 2; 1.
DR Pfam; PF02820; MBT; 2.
DR Pfam; PF17208; RBR; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 2.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51079; MBT; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT REPEAT 24..122
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 130..231
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 615..684
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 75786 MW; 9EE884251902FE22 CRC64;
MDVKKENQEK PPHSGTSSVQ NDDFHWENYL KETGSLSAPS ECFRQSKVPP ANDFKVGMKL
EAHDPRNMTS ICIATVVGIT GARLRLRLDG SDNRNDFWRL VDSPDIQPIG TCEKEGDLLQ
PPLGYQMNAS SWPMFLLRTL NGSEMAPATI FKKEPPKPPL NNFKVGMKLE AIDKKNPYLI
CPATIGDVRG DEVYITFDGW SGAFDYWCKY DCRDIFPVGW CRLTGDVLQP PGTHVPVTKN
IAKTQSSLSK ATQHSMQSPQ KTAVILPTQQ IRKSGRIKPP GQTSVPKKGS AVKNLTPRKK
GPKKEKYFPV LCSTSSASIK SLARDRRVSY DKDATPGTSK IVMSTVCVYV NKHGNSGPLL
DQKKIQQLPD HFGPGPVNVV LRRTVQACVD CAIESKTVFG FLKPDHRGGE VITASFDGET
HSVQLPPVNS ASFALRFLET LCHSLQCDNL LSSQPFSSYR GNTCSPAEHD KKSVKEDVTQ
KSPKRPSQEP PPYVVPVSPK LPKTKVYASK EEQLSCEGSG MPKEEKLSED SKNSPPNPAN
ALSPTSRNPV STHAAVSRSF SPSMPSTSSS ALVGTKSTKS SHHEVKFQMQ KKSEAPSYIA
VPDPSVLKQG FSKDPSTWSV DEVIQFMKHK DPHISGPLAD LFRQHEIDGK ALLLLKSDVM
MKYMGLKLGP ALKLCYYIEK LKEGKYN
//
