ID A0A2Y9JRU8_ENHLU Unreviewed; 394 AA.
AC A0A2Y9JRU8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Bone morphogenetic protein 15 {ECO:0000313|RefSeq:XP_022363747.1};
GN Name=LOC111150546 {ECO:0000313|RefSeq:XP_022363747.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022363747.1};
RN [1] {ECO:0000313|RefSeq:XP_022363747.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022363747.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_022363747.1; XM_022508039.1.
DR AlphaFoldDB; A0A2Y9JRU8; -.
DR STRING; 391180.A0A2Y9JRU8; -.
DR KEGG; elk:111150546; -.
DR OrthoDB; 5301288at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF22; BONE MORPHOGENETIC PROTEIN 15; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..394
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016166024"
FT DOMAIN 266..394
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 394 AA; 45409 MW; 503B16B93A37F8F6 CRC64;
MVLLSILRIL LWGLLLFMEH RVQMAKVGQP SIALMADAPS LPLIWELLEE APGQQQRKPQ
VLGHPLRYML ELYQRSADAR GHPRENRTIG ATMVRLVRPL ANVARPLRGP WHIKTLDFPL
RPNQVAYQLV RAIVVYRHEL HRAHFHLFCH MQPWLQKSQT NHFPSSGRGF SKPSFLSKAW
TEVDITQHVR QRLWNPKGRR VLRLRFMCQH QKGSEILELQ WHGTSSLDTA FLLLYFNDTH
ESVQKTKLHP RGLEKFMGRD SSLLLRRARQ ANSIISGVPG LSGEQDRPQS KKCSLQPFQV
SFHQLGWDHW IIAPYLYTPN YCKGSCPRVL HYGLNSPNHA IIQNLVNELV DQSVPQPSCI
PNKYVPISIL LVEANGSILY KEYEDMVAQS CTCR
//
