ID A0A2Y9JS02_ENHLU Unreviewed; 484 AA.
AC A0A2Y9JS02;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=ETS domain-containing protein Elk-1 isoform X1 {ECO:0000313|RefSeq:XP_022363798.1};
GN Name=LOC111150586 {ECO:0000313|RefSeq:XP_022363798.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022363798.1};
RN [1] {ECO:0000313|RefSeq:XP_022363798.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022363798.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_022363798.1; XM_022508090.1.
DR AlphaFoldDB; A0A2Y9JS02; -.
DR STRING; 391180.A0A2Y9JS02; -.
DR KEGG; elk:111150586; -.
DR OrthoDB; 2884081at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF178; ETS DOMAIN-CONTAINING PROTEIN ELK-1; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 56..137
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 169..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 50886 MW; 1A40646EBB1E10D5 CRC64;
MMLLWEQKRR QDGKKGLLLL LTFATSCVHS LSALSCLPSR YPWDGVSTPP AMDPSVTLWQ
FLLQLLREQG NGHIISWTSR DGGEFKLVDA EEVARLWGLR KNKTNMNYDK LSRALRYYYD
KNIIRKVSGQ KFVYKFVSYP EVARCSTEDC PPQPEVSVTS TVANVATTAV HAAPGDTASG
KPGTPKGAGM AGPGGLARSS RNEYMRSGLY STFTIQSLQP QPPPHPRPAS VLPNTAPSGA
AVPPSGSRST SPSPLEACLE AEEAGLPLQV ILTPPEAQNP KSEELNVEPG SGRSLPPEVK
VDGPKEELEP AVGGEAGFVQ EAAKAGPEVP PAEGVPARLP AVVMETAAPV GGLPASTASS
TEIAQPQKGR KPRDLELPLS PSLLGGPGPE RTPGSGTGSG LQAPGPALTP SLLPTHTLTP
VLLTPSSLPP SIHFWSTLSP IAPRSPAKLS FQFPSSGSAQ VHIPSISVDG LSTPVVLSPG
PQKP
//
