ID A0A2Y9JSW2_ENHLU Unreviewed; 667 AA.
AC A0A2Y9JSW2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Zinc finger protein 182 isoform X2 {ECO:0000313|RefSeq:XP_022363786.1};
GN Name=LOC111150579 {ECO:0000313|RefSeq:XP_022363786.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022363786.1};
RN [1] {ECO:0000313|RefSeq:XP_022363786.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022363786.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022363786.1; XM_022508078.1.
DR AlphaFoldDB; A0A2Y9JSW2; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR23235:SF147; ZINC FINGER PROTEIN 2-LIKE-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 54..125
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 262..289
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 290..317
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 318..345
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 346..373
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 374..401
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 402..429
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 430..457
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 458..485
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 486..513
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 514..541
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 542..569
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 570..597
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 598..625
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 626..653
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 76670 MW; FD0541FF96FAC84A CRC64;
MKLSLRTSLP FPKKNRKWPN PRSRLEEDED LRIPTHALSQ PVPPKPVPPT KGLVTFEDVA
VDFTPEEWQY LNPPQKTLYR EVMLETYSNL VSVGPQGTKP DLILKLEVKE PCLGETKISF
WSFPAVCQIG EQIERQHQDD QDRYLLMQVG FPDKKTIITK TGHDYNEFGN AFHLNTNLVA
SIQRSHKYEP FGNNMVDSLD LFTRSSVGKK YDSGCAKLFF HTEYEKTTPG VKPHGYKECG
KAHRRKKGLS LQERIKNGEK PFECTACRKT FSKKSHLIVH WRTHTGEKPF GCTECGKAFS
QKSQLIIHLR SHTGERPFEC PECGKAFREK STVIIHYRTH TGEKPYECNE CGKAFTQKSN
LIVHQKTHTG EKTYECTKCG ESFIQKLDLI IHHSTHTGKK PHECNECKKT FSDKSTLVIH
QRTHTGEKPH KCAECGKSFN EKSTLIVHQR THTGEKPYEC DVCGKTFTQK SNLGVHQRTH
SGEKPFECNE CEKAFSQKSY LMLHQRGHTG EKPYECSECE KAFSQKSYLI IHQRTHTEEK
PYKCNECGKA FREKSKLIIH QRIHTGEKPY ECPVCWKAFS QKSQLIIHQR THTGEKPYAC
SECGKAFREK STFTVHQRTH TGEKPYKCAE CGKAFTQKSN LIVHQRTHTG KKAHAKGHSR
KSKLITH
//
