ID   A0A2Y9JVE6_ENHLU        Unreviewed;       732 AA.
AC   A0A2Y9JVE6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Eosinophil peroxidase {ECO:0000313|RefSeq:XP_022365067.1};
GN   Name=LOC111151375 {ECO:0000313|RefSeq:XP_022365067.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022365067.1};
RN   [1] {ECO:0000313|RefSeq:XP_022365067.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022365067.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC         Evidence={ECO:0000256|ARBA:ARBA00001970};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022365067.1; XM_022509359.1.
DR   AlphaFoldDB; A0A2Y9JVE6; -.
DR   STRING; 391180.A0A2Y9JVE6; -.
DR   KEGG; elk:111151375; -.
DR   OrthoDB; 4560at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd09824; myeloperoxidase_like; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxidase {ECO:0000313|RefSeq:XP_022365067.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           35..732
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015877720"
FT   BINDING         491
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   732 AA;  82439 MW;  BAA4176EAFD2142E CRC64;
     MQVSIPCPAV ARGLTAEKKL FLALAGVLAA LILALPCEST GSASPATVET SVLRDCITEA
     KLLVDAAYNQ TQRSITERLR SGLASPMDLL SYFKQPLATT RTVVRAADYM HVALELLEGK
     LQLQGSSSLN VTDVLTEPQL RLLSQASGCA LQDQEEKCSN KYRTITGRCN NRRRPLLGSS
     NQALARWLPA EYEDRLSLPF GWTPNRRRNG FLLPLVRAVS NQIVRFPSER LTSDRGRALM
     FMQWGQFIDH DLDFAPESPA RVAFTAGVDC EKSCAQLPPC FPIKIPPNDP RIRNQRDCIP
     FFRSAPACPQ NRNKVRNQLN SLTSFLDASM VYGSEVSLAL RLRNQTNFLG LLAVNTRFSD
     NGRALLPFDN LRDDPCLLTN REARIPCFLA GDSRSSETPK LAAMHTLFMR EHNRLATELK
     RLNPQWTGDK LYQEARKIVG AMVQIITYRD FLPLVLGKAR ARRTLGPYRG YCSKVDPRVA
     NVFTLAFRFG HTMLQPFMFR LDSQYRASAP NSRVPLSTSF FASWRVVHEG GIDPIIRGLM
     ATPAKLNRQD SILVDELRDR LFQQVRRIGL DLAALNMQRS RDHGLPGYNA WRHFCGLSQP
     RNLAQLSRVL QNQGLARKFL NLYGTPDNID IWIGAIAEPL LPGARVGPLL ACLFENQFRR
     ARDGDRFWWE KRGVFTKRQR KALRKISLSR IVCDNTGITT VSRDIFRANT YPRGFVSCTS
     IPKLNLSAWR GT
//