ID   A0A2Y9JVH8_ENHLU        Unreviewed;       450 AA.
AC   A0A2Y9JVH8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Keratin, type I cytoskeletal 25 {ECO:0000256|ARBA:ARBA00040316};
DE   AltName: Full=Cytokeratin-25 {ECO:0000256|ARBA:ARBA00041715};
DE   AltName: Full=Keratin-25 {ECO:0000256|ARBA:ARBA00042483};
DE   AltName: Full=Type I inner root sheath-specific keratin-K25irs1 {ECO:0000256|ARBA:ARBA00043217};
GN   Name=LOC111151400 {ECO:0000313|RefSeq:XP_022365102.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022365102.1};
RN   [1] {ECO:0000313|RefSeq:XP_022365102.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022365102.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_022365102.1; XM_022509394.1.
DR   AlphaFoldDB; A0A2Y9JVH8; -.
DR   STRING; 391180.A0A2Y9JVH8; -.
DR   KEGG; elk:111151400; -.
DR   OrthoDB; 4640531at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF160; KERATIN, TYPE I CYTOSKELETAL 25; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          79..394
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          83..117
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          252..358
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   450 AA;  49327 MW;  7293B4FD5C633430 CRC64;
     MSLRLSSGSR RACPRATAGS LRLSGGGTSF GAGNACSMPG IGSGFSCAFG GSSSGGNAGG
     SNLCAGFTLN EGGLLSGNEK VTMQNLNDRL ASYLENVRAL EEANADLEQK IKGWYEKFGP
     GSCRGLDHDY SRYFPIIDDL KNQIIASTTS NAHAVLQIDN ARLTADDFRL KYENELALHQ
     SVESDVNGLR RVLDEITLCR TDLEIQYETL SEEMTYLKKN HKEEMQVLQC AAGGNVNVEM
     NAAPGVDLTV LLNNMRAEYE ALAEQNRRDA EAWFNEKSAS LQQQISEDVG ATTSARNELT
     EMKRNLQTLE IELQSLLATK HSLECSLTET EGNYCAQLAQ IQAQIGALEE QLHQVRTETE
     GQKLEYEQLL DIKVHLEKEI ETYCLLIGGE DGACKSGGYK SKDYGSGNMG NQVRDLAKAI
     VVKKVLEEVD QRSKILTTRL HSLEEKSQNN
//