ID A0A2Y9JVI8_ENHLU Unreviewed; 477 AA.
AC A0A2Y9JVI8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Septin-4 {ECO:0000256|ARBA:ARBA00040438};
GN Name=LOC111151345 {ECO:0000313|RefSeq:XP_022365003.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022365003.1};
RN [1] {ECO:0000313|RefSeq:XP_022365003.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022365003.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000256|ARBA:ARBA00004398}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|RuleBase:RU004560}.
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DR RefSeq; XP_022365003.1; XM_022509295.1.
DR AlphaFoldDB; A0A2Y9JVI8; -.
DR STRING; 391180.A0A2Y9JVI8; -.
DR KEGG; elk:111151345; -.
DR OrthoDB; 5396944at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF71; SEPTIN-4; 1.
DR Pfam; PF00735; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 140..413
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 38..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 55057 MW; F66C03749C6ADF8A CRC64;
MDHSLGWQSS SVPEDRTEAG IKCFLEDTDD TELNKFVKDF PGSESCHQPE AKTWGSKPQV
LEPRPQAPDL YQDDLEFRPP SWSQASDSQQ CFSASAPLSP SARPRSPWGK LDPYDSSEDD
KEYVGFATLP NQVHRKSVKK GFDFTLMVAG ESGLGKSTLV NSLFLTDLYR DRKLLSAEER
IMQTVEITKH AVDIEEKGVR LRLTIVDTPG FGDAVNNTEC WKPVAEYIDQ QFEQYFRDES
GLNRKNIQDN RVHCCLYFIS PFGHGLRPLD VEFMKALHQR VNIVPILAKA DTLTPPEVER
KKRKIREEIE RFGIKVYQFP DCDSDEDEDF KLQDQALKES IPFAVIGSNT VVEARGRRVR
GRLYPWGIVE VENPGHCDFV KLRTMLVRTH MQDLKDVTRE THYENYRAQC IQSMTRLVVK
ERNRNKLTRE SGTDFPIPAV PPGTHPETER LIREKDEELR RMQEMLHKIQ RQMEETH
//
