ID   A0A2Y9JWN1_ENHLU        Unreviewed;       993 AA.
AC   A0A2Y9JWN1;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Rab GTPase-activating protein 1-like isoform X2 {ECO:0000313|RefSeq:XP_022363929.1};
GN   Name=LOC111150680 {ECO:0000313|RefSeq:XP_022363929.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022363929.1};
RN   [1] {ECO:0000313|RefSeq:XP_022363929.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022363929.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022363929.1; XM_022508221.1.
DR   AlphaFoldDB; A0A2Y9JWN1; -.
DR   Proteomes; UP000248482; Unplaced.
DR   CDD; cd01211; PTB_Rab6GAP; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   PANTHER; PTHR47219:SF7; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          78..193
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          480..666
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   REGION          49..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          970..993
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          749..854
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          907..962
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        49..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..420
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   993 AA;  113267 MW;  042CDF754BA003BC CRC64;
     MEEILRDSEK GQSTLLVDCQ SSTEISEHSF GDISASQTNK PSLQLILDPS NTEVSTPRPS
     SPSGLPEEDS VLFNKLTYLG CMRVSSPRNE VEALRAMATM KSSSQHPFPV TLYVPNVPEG
     SVRIIDQSNN VELASFPIYK VLFCARGHDG TTESNCFAFT ESSHGSEEFQ IHVFSCEIKE
     AVSRILYSFC TAFKRSSRQV TDVKDSIIPT PDSDVFTFSV SLEVKEDDGK GNFSPVPKDR
     DKFYFKLKQG IEKKVVITVQ QLSNKELAIE RCFGMLLSPG RNVKNSDMHL LDMESMGKSY
     DGRAYVITGM WNPNVPIFLA LNEETPKDKR VYMTVAVDMV VTEVVEPVRF LLETVVRVYP
     ANERFWYFSR KTFTETFFMR LKQSEGKGHT NAGDAIYEVV SLQRQSEKEE PVTPTSGGGP
     MSPQEDEAEE ESDNELSSGT GDVSKDCPEK ILYSWGELLG RWHSNLGARP KGLSTLVKSG
     VPEALRAEVW QLLAGCHDNQ AMLDRYRLLI TKDSAQESVI TRDIHRTFPA HDYFKDTGGD
     GQESLYKICK AYSVYDEDIG YCQGQSFLAA VLLLHMPEEQ AFCVLVKIMY DYGLRDLYKN
     NFEDLHCKFY QLERLIQEQL PDLHHHFCVL NLEVHMYASQ WFLTLFTAKF PLCMVFHIID
     LLLCEGLNII FNVALALLKT SKEDLLQADF EGALKFFRVQ LPKRYRAEEN ARRLMEQACN
     IKVPTKKLKK YEKEYQTMRE SQLQQEDPMD RYKRENRRLQ EASMRLEQEN DDLAHELVTS
     KIALRNDLDQ AEDKADVLNK ELLLTKQRLV ETEEEKRKQE EETAQLKEVF RKQLEKAEYE
     IKKTTAIIAE YKQICSQLST RLETQQAASR EELEVVKGKM MACKHCSDIF SKEGALKPAA
     VSREEQGVDL DDEKDNLKKQ LREMELELAQ TKLQLVEAKC KIQELEHQRG ALMNEIQAAK
     NSWFSKTLNS IKTATGTQPL QPPPATQPPK EST
//