ID A0A2Y9JX60_ENHLU Unreviewed; 3110 AA.
AC A0A2Y9JX60;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 10-FEB-2021, entry version 12.
DE SubName: Full=centromere protein F {ECO:0000313|RefSeq:XP_022364119.1};
GN Name=LOC111150802 {ECO:0000313|RefSeq:XP_022364119.1};
OS Enhydra lutris kenyoni.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Lutrinae;
OC Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022364119.1};
RN [1] {ECO:0000313|RefSeq:XP_022364119.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022364119.1};
RG RefSeq;
RL Submitted (OCT-2020) to UniProtKB.
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DR RefSeq; XP_022364119.1; XM_022508411.1.
DR KEGG; elk:111150802; -.
DR Proteomes; UP000248482; Genome assembly.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1890..2032
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2128..2267
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2310..2448
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2966..3009
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 245..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1717..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2901..3110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..138
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 350..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 418..459
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 467..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 651..713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 718..752
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 838..865
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 902..946
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 954..991
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1028..1083
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1117..1151
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1291..1318
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1330..1357
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1395..1415
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1547..1610
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1787..1814
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1822..1856
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1887..1907
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1936..1994
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1999..2082
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2104..2124
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2139..2201
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2209..2275
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2293..2313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2321..2348
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2356..2492
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2500..2600
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2615..2713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2715..2822
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2830..2860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2868..2888
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 246..264
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..533
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2901..2928
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2951..2980
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2995..3009
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3020..3074
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3110 AA; 356979 MW; B4FF30D8A986194C CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ AAQAAEVSLH PSTTPQKIFA TPLTPSQYYT GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKTSQAIPQN TMNHRDIARH QASSSVFSWQ QEKTPTRLSS NALKTPIRRE
FSASHFSGEQ EVTPSRSTLQ TGKRDANGSF CDNSSNSHLL DQLKAQNQDL RNKISELELH
LQGQEKEMKG QANKCQELQL QLEKAKAELV EKEKILNKNR DELVRSTAQY DQASTKCTTL
EQKLKRLSED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL CRQQRAFQAL DQECVQMKAR
LTQELQQAKN TRNILQADLD KVTSGKHQLE KTLEEFKQKF CRTEQALQAS QVQENELRRS
SEEVKKEFSV LKSQSEQRAR EVCHLEEELR KARQSLSQSQ NATEEMRAKN ASQETMLRDL
QEKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNDKLSK IEKESEALLL
ALELKKKDCE ELKEEKALFA RWKSENEQLL SQLESEKGSL QSKINHLETC LKTQQIRSHE
YNEKVRTLEM ESENLSVEIR NLHNVIDSKT VEVERQKQAY ADLQQKAEFS DQKHKKEVEN
MCLKISELTG QVDDLEHKLQ LLSSEVIDKD QRYQDSQAEY ENLQDLVKSK DSSLVTNEAL
NRSLLAFEQQ PAMNNSFAIT GEQGSMPSER STCHLEADPS PKNSAILQNR VVSLEFSLES
QKQMNSDLQK QCEELVQIRG EIEENLIKAE QMHQSFVAET SQRISKLQED TSVHQNAFTE
TLAALENKER EFQLLNEKLE TEQAEIQELK KSNHLLQDSL KELQLLSEAL SLEKKEMSST
ISLNRKEIED LTQENATLKE INATLNQEKI NLLQKSESFV NCIDERDKSI SELSNQHKQE
RLILQQRCEE TGHALEDLSE KYSAAQEKNS QLECLLNECT IACENRQKEL EHLKETFARE
QQDFVTKLAL AEETNQNLVL ELGAVRHDLS SEIADIQNNS KSEADGLKQE IMTLKEEQSK
MQKELNALLQ ENEHLVTLMK TKQEHQILES EPVSDAVEGV SEINKCHIQL PMDLEVKDPS
LDCHNAQLVQ LEAKRIRELK LQESEKGKEC PLHELCTIRM ELETGNLQPE AQSPEPSGPK
DCDVGTEEKY MSVLHELSAS QNDHAHLLCS LQTAMSKLSE LEKMCEMLQV EKLELMSELN
DSRSECITAT NKMAEEMEKL VNEVKILNNE NGLLQGELVK EMAEGESCER QNEQKRASLN
PLGDSNCYEH LTLSNKEVQM HFAELQEKFS SLQSEHKILH DQHRQVSSKM SELQSYVDTL
KAENSILSTS LRSFQGDLVK EEMPGPEEGH FLSLSFSCVT DSPGLTRLGE SSFCKDILDQ
TGETSLLNNL DGTISANQSN VEERSCCSLE EENLTKKEIL SAPARSVEEL ETLCQMYMQS
LKELEEKIES QEIMKNKEIK ELEQILSSER EELDCLRKQY LSENEQWQQK LTSVTMEMES
KLAAEKKQTE HLSFELEVAR LQLQGLDLSS RSLLGTDIED VLRGGNNSCD VKESEEYTLE
TQERTPKRDI HQICEEGIQQ DLSREMEKIT KTSPVRFTGE EWSREQSPET PAEDKTQGYL
ECISQLSLSG PNAPVPVDFL ETQVTIQNLQ LQVKESSNEN LRLLHVIEER DKKVESLLNE
IKELDSKLDL QEAQITTKTE ACVELEKIVG KLKKEKSNLR ERLESFACDN QELHQRTESL
EGLNSNLETG TDKRSHAVIE ENMAEVNDNW RERFLDVEKE LKRIQSEKGS IEHHALSVEA
DLETVQTEKL YLEKDNESKQ KLITCLEEEL SVVTNERNQL HGELDTLSKE NKELDLMSEK
MKEKIHELES HQDECLHHID VAEAELKDKA QLIQTLSSNV TELSEENTRL QEQLQSLEKD
SQALSLVKSE LEIQIEQLNK EKESLAGESE SLQTRLHESE HEKLTIAKAL EDALMEKGEV
AVRLSSTQEE VHQLRKGIEK LRVRIEADDK KQLHVLEKLR VSERKNDSLQ DKVENLEREL
QMSEENQELV ILDAENSKAE VEALKTQMEL MTKTLKDLEL DLGTVKFEKE NLIKQLQEKQ
GQVSELDTLL SSLKSRLEEE EKEKIETREE SKAALEMLQT QLKELNEEVI ALCHDQEIQK
VEEQSMDISG QKIHQLRNSI EKLKVRLEAD EKEQLQVLRK LKESEHHADL LKDRVENLER
ELEISGKNQE CMILEAENSK AEVGTLKAKI EEMAQNLRDL ELDLVHIRSE KENVIEELQK
AQGRVSELEI LKSSFENLLQ EKEQEKIQMR EDSKIAVEML QTQVKELNQK AEALCHDQEA
WKAQAQNLHS QVDALELEKT QLLQDLDEVK NNYLNVQSSA NGLLQQVEDG KHKLEKKEEE
ISLLKNQIQD REQLTSKLAQ VEGEQQLWKK QKGELENLLV ELEQKSQVLQ AKNDTLQDTL
EALQRSHKDL EKELELRKME NVSFVEKVNA MTGKETELQR EMHEMVQKTT ELKEEFTRER
NRLTEELNIM SEDIKSSKGQ LKELMLENSE LKKSLDCIHK DQMEKEEKVR EEIAEYQLQL
QEAEKKHQAL LLDTNKQYEM EIQTYREKLS SQEECLSSQK AEVDLLKSSK EELNNSLKAT
TQILEELKKT QADNVKYANQ LKKENERAQG KIKLLIKSCK QLEEEKEMLQ KELSKIEAAQ
EKQKTGTAVD SNVEELMAEI KELKETLEEK NKEADEYLDK YCSLLISHEK LEKAKEMLET
QVARLSSQSK LNLQNSPLLN SVVSEDSPAP SATEKKLSSS QNKTSGKRQR STGIREDGGG
TAPSTPETFS KKSRKAVKSG IHPTEDTRDT EFEPEGLPEV VKKGFADIPT GKTSPYVLRR
TTMPTRTSPR LAAQKLAPSP LSLNKENQAE TSQPTAGGSR SQKVKVAQQS PVDSSAPFRE
PTTRSLSVSN LPDRSPADSP REGLRAKRGR LAPSPEAVPD SKSSENCRVQ
//
