ID A0A2Y9JXB8_ENHLU Unreviewed; 1206 AA.
AC A0A2Y9JXB8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Fibronectin type III domain-containing protein 3B {ECO:0000313|RefSeq:XP_022364174.1};
GN Name=LOC111150836 {ECO:0000313|RefSeq:XP_022364174.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022364174.1};
RN [1] {ECO:0000313|RefSeq:XP_022364174.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022364174.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FNDC3 family.
CC {ECO:0000256|ARBA:ARBA00038207}.
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DR RefSeq; XP_022364174.1; XM_022508466.1.
DR AlphaFoldDB; A0A2Y9JXB8; -.
DR STRING; 391180.A0A2Y9JXB8; -.
DR KEGG; elk:111150836; -.
DR OrthoDB; 316463at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF11; FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED; 1.
DR Pfam; PF00041; fn3; 8.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 9.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1181..1204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 280..379
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 383..475
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 479..572
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 576..671
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 675..767
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 768..861
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 873..959
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 960..1054
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1058..1155
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 185..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1206 AA; 132951 MW; 2DA28EC095BB06EF CRC64;
MYVTMMMTDQ IPLELPPLLN GEVAMMPHLV NGDAAQQVIL VQVNPGETFT IRAEDGTLQC
IQGPAEVPMM SPNGSIPPIH VPPGYISQVI EDNTGVRRVV VTPQSPECYP PSYPSAMSPT
HHLPPYLTHH PHFIHNSHTA YYPPVTGPGD MPPQFFPQHH IPPTIYGEQE IIPLYGMSSY
ITREDQYSKP PHKKLKDRQI DRQNRLNSPP SSIYKSNCTP VYNGYGKGHS AGGSGGSGGS
GGGPGIKKTE RRARSSPKST DSDLQEYELE VKRVQDILSG IEKPQVSNIQ ARAVVLSWAP
PVGLSCGPHS GLSFPYSYEV ALSDKGRDGK YKIIYSGEEL ECNLKDLRPA TDYHVRVYAM
YNSVKGSCSE PVSFTTHSCA PECPFPPKLA HRSKSSLTLQ WKAPIDNGSK ITNYLLEWDE
GKRNSGFRQC FFGSQKHCKL TKLCPAMGYT FRLAARNDIG TSGYSQEVVC YTLGNIPQMP
SAPRLVRAGV TWVTLQWNKP EGCSPEEAVT YTLEIQEDEN DNVFHPKYTG EDLTCTVKNL
KRSTQYKFRL TASNVEGKSC PSEVLVCTTS PDRPGPPTRP LIKGPVTSHG FSVKWDPPKD
NGGSEILKYL LEITDGNSEA SQWEVAYSGS ATEYTFTHLK PGTLYKLRAC CISTGGHSQC
SESLPARTLS IAPGQCRPPR VLGRPKHKEV HLEWDVPASE SGCEVSEYSV EMTEPEDVAS
EVYHGPELEC TVGNLLPGTV YRFRVRALND GGYGPYSEVS EITTAAGPPG QCKAPCISFT
PDGCVLVSWE SPESSGADIS EYRLEWGEDE ESLELVYHGT DTGFEIRDLL PAAQYCCRLQ
AVNQAGAGPY SELVLCQTPA SAPDPVSTLC VLEEETLNAY PDSPFVCLVL NWEEPCNNGS
EILAYNIDLG DTSITVANTT THVIKDLLPE TTYRIRIQAV NEIGAGPFSQ FIRAKTRPLP
PLPPRLECAA AGPQSLKLKW GDSNTKTHAA DDLVYTLQLE DRNKRFISIY RGPSHTYKVQ
RLTEFTCYSF RIQAASEAGE GPFSETYTFS TTKCIPPTIK APRVTQLEGN SCEIFWETVP
PMKGDPVHYI LQVLVGRESE YKQVYKGEEA TFQISGLQTN TDYRFRVCVC RRCVDTAQEL
SGAFSPSAAF VLQRSEVMLP GDTGSLDDPK MKSMMPTDEQ FAALIVVGFA TLSILFAFIL
QYFLMK
//
