ID A0A2Y9JZM0_ENHLU Unreviewed; 797 AA.
AC A0A2Y9JZM0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Adhesion G-protein coupled receptor G7 isoform X2 {ECO:0000313|RefSeq:XP_022366311.1};
GN Name=LOC111152205 {ECO:0000313|RefSeq:XP_022366311.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022366311.1};
RN [1] {ECO:0000313|RefSeq:XP_022366311.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022366311.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_022366311.1; XM_022510603.1.
DR AlphaFoldDB; A0A2Y9JZM0; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR47767; ADHESION G PROTEIN-COUPLED RECEPTOR G7; 1.
DR PANTHER; PTHR47767:SF1; ADHESION G-PROTEIN COUPLED RECEPTOR G7; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_022366311.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 435..723
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DOMAIN 449..684
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 797 AA; 88717 MW; 75B3DEF333705E28 CRC64;
MASCRACDLK VLVAIVCGLL TTIVLGLGIW TTVIRIQKEL STSSPSIPME FCRNGGTWEN
GRCICPDFWK GWRCTIANFC ENSTYGIFTF DRIPAGKYGP SRQRCDKDTL NEGNPRATRL
CNITMYGEIK LENVTIGNCN QTLEALEDQI GNISTQSLNI SNEARILTSD VNRITPEGVI
SATKVVGEIF NPERNATLEA KEIAVTTVSQ LLDAGEGVFQ EAAAAGTDDV NTFAMLVKQM
EIYSTSLGNK TVVEPNVAVQ SVDLSSESTG HSTSVRFSVK KGSSDSLIPG STVVERDVEA
LNPNGQTELQ ILLNTSTSNT TACGFVVYQN NKLFQSKTFN TKSDFSQKII SGSTNENNSQ
GASVDIVFNP KYNQKEFQLH SYACVYWNLS TKDWDTRGCY KNGNADDFLY CHCNHTTNFA
VLMSFKKNYK YPESLNILSS VGCALSITGL VLTIIFQIAT RNVRKTSVTW VLVSLCVSML
IFNLLFVFGI ENSNKNLKES DSDTNKPDSN RNEMLTQDTV YIPNPKCTVV AALLHYFLLV
TFSWTGLSAA QLYFLLIRTM RPLPQRFILF ISLIGWGVPA IVVVVTVGII FSQSGSQWEL
DYRQEEICWL AVSGKNGLIT SSLLWSFIMP ITIILINNIV IFIIIIVKVI WKTNQNLTST
KKVSFLKKIL STLSITVVFG VTWILAYFML IGNDDVREIF SYMFCLFNTT QGLQIFILYT
VKTKIFQSEA SKVLKSLSES TGRVKLLPSV TPLRLRLRMY NLLTSFPALN ERFTLLEPSV
IMEEMTPSES DQADSSI
//
