ID A0A2Y9JZW2_ENHLU Unreviewed; 831 AA.
AC A0A2Y9JZW2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC111152251 {ECO:0000313|RefSeq:XP_022366406.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022366406.1};
RN [1] {ECO:0000313|RefSeq:XP_022366406.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022366406.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR RefSeq; XP_022366406.1; XM_022510698.1.
DR STRING; 391180.A0A2Y9JZW2; -.
DR KEGG; elk:111152251; -.
DR OrthoDB; 912242at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47634; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR47634:SF4; SRSF PROTEIN KINASE 1; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_022366406.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 256..829
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..111
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..235
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 285
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 831 AA; 92844 MW; 88854AFED672E33A CRC64;
MERKGERWIG LRHEGQRPAG RGPSQHXELS LTAAVRSPGV RRPPSEVAPP LTPRLWAAGP
RPSAPASFRA GSHRPLFPSR PTRALGPLQG PALGEPDRPP PAGPLTRPVP PPAHPAWALL
CAPWAARRPA GRLALAAALA PEPPLRRAPH PGLAPLLGLH PHLDCLLSST FALHPSLSPA
VLALQARKKR TKAKKDKAQR KSEIQHRGSA PHSESDLPEQ EEEILGSDDD EQEDPNDYCK
GGYHLVKIGD LFNGRYHVIR KLGWGHFSTV WLSWDIQGKK FVAMKVVKSA EHYTETALDE
IRLLKSVRNS DPNDPNREMV VQLLDDFKIS GVNGTHICMV FEVLGHHLLK WIIKSNYQGL
PLPCVKKIIQ QVLQGLDYLH TKCRIIHTDI KPENILLSVN EQYIRRLAAE ATEWQRSGAP
PPSGSAVSTA PQPKPADKMS KNKKKKLKKK QKRQAELLEK RMQEIEEMEK ESGPGQKRPN
KQEESESPVE RPLKENPPNK MTQEKLEESS TIDQDQTLME RGVEGGAAEI NCNGVIEIVN
YTENSNKETL RLKEDLHNAN DCDVQNLKQE TSFLSSQNGD SSTSQETDSC TPVTSEVSDT
MMCQASPNVD QSFSEQDISQ LQESIRAEIP CEDEHEQEQN GPLDNKGKST AGNFLVNPLE
PKNAEKLQVK IADLGNACWV HKHFTEDIQT RQYRSLEVLI GSGYNTPADI WSTACMAFEL
ATGDYLFEPH SGEEYTRDED HIALIIELLG KVPRKLIVAG KYSKEFFTKK GDLKHITKLK
PWGLFEVLVE KYEWSQEEAA GFTDFLLPML ELIPEKRATA ADCLRHPWLN S
//
