ID A0A2Y9K080_ENHLU Unreviewed; 2646 AA.
AC A0A2Y9K080;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Dystonin isoform X4 {ECO:0000313|RefSeq:XP_022366531.1};
GN Name=LOC111152327 {ECO:0000313|RefSeq:XP_022366531.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022366531.1};
RN [1] {ECO:0000313|RefSeq:XP_022366531.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022366531.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_022366531.1; XM_022510823.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00681; Plectin; 4.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00250; PLEC; 11.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF75399; Plakin repeat; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR SUPFAM; SSF57997; Tropomyosin; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 562..619
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 409..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 883..917
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1134..1326
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1350..1727
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1791..1864
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2646 AA; 305917 MW; BB8A17D479FDCB91 CRC64;
MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN FLSVNCGPTL INSCITFGNE SLDGHRLEML
QQIANRVQRD SVICEDKLIL ARNALQSDSK RLESGVQFQN EAEIAGYILE CENLLRQHVI
DVQILIDGKY YQADQLVQRV AKLRDEIMAL RNECSSVYSK GRMLTMEQTK LMISGITQSL
NSGFAQTLNP SLNSGLTQGL TPSLTPSSVT SGLSSGLTSR LTPSVTPAYT PGFPSGGLVP
SFSSGVETNS LQTLKLMQIR KPLLKSSLLD QNLTEEEVNM KFVQDLLNWV DEMQVQLDRT
EWGSDLPSVE SHLENHKNVH RAIEEFESSL KEAKISEIQM TAPLKLTYAE KLHRLESQYA
KLLNTSRNQE RHLDTLHNFV TRATNELIWL NEKEEEEVAY DWSERNTNIA RKKDYHAELM
RELDQKEENI KSVQEIAEQL LLENHPARLT IEAYRAAMQT QWSWILQLCQ CVEQHVKENT
AYFEFFNDAK EASDYLRNLK DAIQRKYSCD RSSSIHKLED LVQESMEEKE ELLQYKSTIA
SLMGRAKTII QLKPRNPDCP LKTSIPIKAI CDYRQIEITI YKDDECVLAN NSHRAKWKVI
SPTGNEAMVP SVCFTVPPPN KEAVDFANRI EQQYQSVLTL WHESHINMKS VVSWHYLINE
IDRIRASNVA SIKTMLPGEH QQVLSNLQSR FEDFLEDSQE SQIFSGSDIT QLEKEVNVCK
QYYQELLKSA EREEQEESVY NLYISEVRNI RLRLESCEDR LIRQIRTPLE RDDLHESVFR
ITEQEKLKKE LERLKDDLGT ITNKCEEFFS QAATSASVPT LRSELGVVIQ NMNQVYSMSS
TYIEKLKTVN LVLKNTQAAE ALVKLYETKL CEEEAVIADK NNIENLISTL KQWRSEVDEK
REVFHALEDE LQKAKAISDE MFKTYKERDL DFDWHKEKAD QLVERWQNIH VQIDNRLRDL
EGIGKSLKYY RDTYHPLDDW IQQVETTQRK IQENQPENSK TLATQLNQQK MLVSEIEMKQ
SKMDECQKYA EQYSTTVKDY ELQTMTYRAM VDSQQKSPVK RRRMQSSADL IIQEFMDLRT
RHTALVTLMT QYVKFAGDSL KRLEEEEIKR CKETSEHGAY SDLLQRQKAT MIENSKLTGK
ISELEKMVAE LKKQKSRVEE ELPKVKQAAE NELRKQQRNV EDIALQKIRA ESEAKQYRRE
LETIVREKEA AERELERVRK LTLEAEAKRA AVEENLLNFQ NQLEENTFTR RTLEDHLKRK
DSSLSDLEQQ KIKLMEELKR KRDNEEELLK LIKQMEKDLT FQKQIAEEQL KEKQKIESEA
RRKISEIQYS CRESALPLAT SYRGVADLQR EQDRQKTEEL KQQVDELTVA NRKAEKDMRD
LKYELNALQL EKTSSEEKAR LLKEKLDETN NTLKCLKLEL ERKDQVEEGY SQQLRELGRQ
LNQTTDKAEE VMQEANDLRK IKHNYEVELE SLQQEKGKLQ REVDRITKTH AIAERNIQHL
NSQVNSFQAE KESSNERIRF CQRKSDHLKE QFEKSHAQLL QNIKAEKENN EKIQKLNEEL
KKSNECAEML KQKVDELTRQ NNETKLMMQR IQTESANVVL EKQAIQQRCE ALKIQADGFK
DQLRNTNEHL HKQTKTEQDF HRKIKCLEED LAKSQNLVSE FKQKCDQQNI IIQNTEKEVR
SLSAELSASK EEKRLGEQKV QLQQAQVQEL NNRLKKVQDE LHLKTIEEQM THRKMVLFQE
ESDKFKCSAE EFRKKMEKLM DSKVITENDI SGIKLDFVSL QRENCRAQEN AKLCETNIRD
LERQLQQYRE QMQQGQNVEA NHYQKCQKLE DELVVQKREV ERLKQKMDQQ IKEHEHQLVL
LQCEIQKRNP AKDCPFKPDF EMTVNECQHS TDVPSRTTGQ LHPATRSSLL RRNQDPQQLE
EKWQHRGVEQ IPKEVQFWPS GGPLEKEKSQ QCYSEYFSQT STELQITFDE TNPITKLSEI
EKIRDQALYS SRPPVRYQDG KCEMDLAKLL APLEIAQNKQ YDMHTEVTTL KQEKSPGPSA
EEWMLGGCRA PGGLQRDLLK KGSEPETFQN VDGDHTCSVR DDEFKFQGLR RTVTGRQLVE
AKLLDAKTVE QLRLGLKTVD EVQKMLSKFL TKATSIAGLY LESTKEKISF ASAAKKIIID
KMMALAFLEA QAATGFIIDP NSGQTYSVED AILNGVIDPE FKIRLLEAEK AALGYSYSSK
TLSVFQAMEN RMLDRQRGKH MLEAQIASGG VIDPVRGIRI PPEVAVQQGL LNNAILQFLH
EPSSNSRVFP NPNNKQALYY SELLRMCVFD VDCQCFLFPF GERNISNLNV GKTHRISVVD
TKTGAELTAY EAFQRNLIEK STYLELSGQQ YQWKEATFFE SYGHPSHMLT DTKTGLQFNI
NEAVEQGTVD KTWVRKYQEG LITLTELADS LLSQLVPKKD LHSPIAGYWL TTSGERISVL
KASRRNLVDR ITALRCLEAQ VSTGGIIDPL TGKKYRVAEA LHRGLVDEGF AQQLRQCEVV
ITGIGHPVTN KVMSVVEAVN ANIISKEMGI RCLEFQYLTG GLMEPQVHSR LSIEEALQVG
IIDVFIATKL KDQKSYVRNI ICPQTKRKLT YKEALEKADF DFHTGLKLLE VSEPLMTGIS
SLYYSS
//
