ID A0A2Y9K0M6_ENHLU Unreviewed; 1224 AA.
AC A0A2Y9K0M6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA polymerase subunit gamma-1 {ECO:0000256|ARBA:ARBA00015350, ECO:0000256|PIRNR:PIRNR000797};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|PIRNR:PIRNR000797};
GN Name=LOC111152617 {ECO:0000313|RefSeq:XP_022366858.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022366858.1};
RN [1] {ECO:0000313|RefSeq:XP_022366858.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022366858.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the replication of mitochondrial DNA. Associates
CC with mitochondrial DNA. {ECO:0000256|ARBA:ARBA00025629}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|PIRNR:PIRNR000797};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Heterotrimer composed of a catalytic subunit and a homodimer
CC of accessory subunits. {ECO:0000256|PIRNR:PIRNR000797}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173,
CC ECO:0000256|PIRNR:PIRNR000797}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|PIRNR:PIRNR000797}.
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DR RefSeq; XP_022366858.1; XM_022511150.1.
DR AlphaFoldDB; A0A2Y9K0M6; -.
DR STRING; 391180.A0A2Y9K0M6; -.
DR KEGG; elk:111152617; -.
DR OrthoDB; 5403095at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 1.20.5.3960; -; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PIRSF; PIRSF000797; DNA_pol_mt; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR000797};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000797};
KW DNA-directed DNA polymerase {ECO:0000256|PIRNR:PIRNR000797};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|PIRNR:PIRNR000797};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|PIRNR:PIRNR000797};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000797}.
FT DOMAIN 862..1136
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 424..451
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1224 AA; 136547 MW; 2EA435302275C4DD CRC64;
MSRLLWKRVA GATTVGPGPV PAPGRWVSSS GPAPVPSDGQ PPSPPQQVPS SEGGQLRHNP
LHIQMLSRGL HEQIFGRGGE TPGEAAVRRS VEHLQRHGLW GQPATPLPDV ELRLPPLYGG
GLDQHFRLLA QKQSLPYLEA ANSLLQAQLP PKPPSWAWAE GWTRYGPAGE AVPVAIPEER
ALVFDVEVCL AEGTCPTLAV AISPSAWYSW CSRRLVEERY SWTSRLSPAD LIPLEVPASA
GGPTRRGWQE QLVVGHNVCF DRAHIREQYL IQGSRMRFLD TMSMHMAISG LSGFQRSLWM
AAKQGKRKAQ HPTQRGQKAP RKASGPAISS WDWLDISSVN NLADVHGLYV GGPPLQKEPR
ELFVKGSMKD IRENFQDLMQ YCAQDVWATY EVFQQQLPLF LERCPHPVTL AGMLEMGVSY
LPVNHNWERY LAEAQSTYEE LQREMKKSLM DLANDACRLL SGQRYKEDPW LWDLEWDLQE
FKQKKAKKVK RKEPTTASKL PIEGAGAPGE PKDQEDPGPP SEEEEVQRDG MARACLERLK
GTAEVLPKRP QHLPGHPGWY RKLCPRLDDP TWTPGPSLLS LQMRVTPKLM AMTWDGFPLH
CSERHGWGYL VPGRRDNLAQ APVETAPASA GVACPYRAIE SLYRKHCLEQ GKQQPEPQQA
GLAEEFLLAD GSAMWQTVEE LGCLEAEAEA EVEARTERCG AAVPSQPPAL TAAGGPKASQ
PAYHHGNGPY NDVDVPGCWF FKLPHKDGSS CNVGSPFAKD FLPKMEDGTL QAGPGGASGP
RALEINKMIS FWRNAHKRIS SQMVVWLPRS ALPRAVTRHP DYDEEGRYGA ILPQVVTAGT
ITRRAVEPTW LTASNARPDR VGSELKAMVQ APPGYVLVGA DVDSQELWIA AVLGDAHFAG
MHGCTAFGWM TLQGRKSRGT DLHSKTAATV GISREHAKIF NYGRIYGAGQ PFAERLLMQF
NHRLTRQEAA EKAQQMYAVT KGLRRYRLSD EGEWLVRELD LPVDRTEDGW VSLQDLRKIQ
REASKKSRWK KWEVVAERAW TGGTESEMFN KLESIAMSDT PCTPVLGCRI SRALEPSAVQ
GEFMTSRVNW VVQSSAVDYL HLMLVAMRWL FEEFAIDGRF CISIHDEVRY LVREEDRYRA
ALALQITNLL TRCMFAYKLG LNDLPQSVAF FSTVDIDRCL RKEVTMDCKT PSNPTGMERR
YGIPQGEALD IYQIIELTKG SLEP
//
