ID A0A2Y9K138_ENHLU Unreviewed; 532 AA.
AC A0A2Y9K138;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=LOW QUALITY PROTEIN: probable histone-lysine N-methyltransferase PRDM7 {ECO:0000313|RefSeq:XP_022367152.1};
GN Name=LOC111152801 {ECO:0000313|RefSeq:XP_022367152.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022367152.1};
RN [1] {ECO:0000313|RefSeq:XP_022367152.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022367152.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_022367152.1; XM_022511444.1.
DR STRING; 391180.A0A2Y9K138; -.
DR KEGG; elk:111152801; -.
DR OrthoDB; 3470369at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd19193; PR-SET_PRDM7_9; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR044417; PRDM7_9_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019041; SSXRD_motif.
DR PANTHER; PTHR14112:SF1; KRAB-RELATED DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14112; SYNOVIAL SARCOMA, X MEMBER; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF09514; SSXRD; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50806; KRAB_RELATED; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 87..150
FT /note="KRAB-related"
FT /evidence="ECO:0000259|PROSITE:PS50806"
FT DOMAIN 90..160
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 308..422
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 22..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 60623 MW; 9B0722080E3C26E3 CRC64;
MYAHREHIPP ASETLRTISL QAHKSLRLHR PQGNSTRFGL GTERLMRPLT ASESEQGLPG
GPSTRSLNRP PEETPERDSG RTGWKPTVRD AFKDISVYFS KEEWTEMGDW EKIRYRNVKR
NYEALITIGL RAPRPAFMCH RRQAIKPQVD DTEDSDEEWT PRQQVRPSWV AFRMEQSKHQ
KGIPRAPLSN EYSLKELSET AKLLNTSGSE QGQKPVSLPG EASTSGQHSL RKLELRRKDV
EVKMYSLRER KSLAYQEVSE PQDDDYLYCE KCQNFFIDSC AVHGPPTFVK DSAVDKGQPN
RSALTLPPGL RIRPSGIPQA GLGVWNEASD LPLGLHFGPY EGQITEDEEA ANSGYSWLIT
KGRNCYEYVD GKDNSWANWM RYVNCARDDE EQNLVAFQYR RQIFYRTCRV IRPGCELLVW
YGDEYGQEXW ASSGEASGRA SSQQGKNQGQ RYIPVLLALW LSPVRNSSAN IWNAITLLRS
SHEYLQENIS SQRIPAQANK ITSSSNILIR RAGMTKLKVK RSKKVSNLCL KV
//
