ID   A0A2Y9K148_ENHLU        Unreviewed;      1150 AA.
AC   A0A2Y9K148;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Fanconi anemia group I protein isoform X3 {ECO:0000313|RefSeq:XP_022366861.1};
GN   Name=LOC111152618 {ECO:0000313|RefSeq:XP_022366861.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022366861.1};
RN   [1] {ECO:0000313|RefSeq:XP_022366861.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022366861.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022366861.1; XM_022511153.1.
DR   AlphaFoldDB; A0A2Y9K148; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd11720; FANCI; 1.
DR   InterPro; IPR026171; FANCI.
DR   InterPro; IPR029310; FANCI_HD1.
DR   InterPro; IPR029312; FANCI_HD2.
DR   InterPro; IPR029308; FANCI_S1.
DR   InterPro; IPR029315; FANCI_S2.
DR   InterPro; IPR029313; FANCI_S3.
DR   InterPro; IPR029314; FANCI_S4.
DR   PANTHER; PTHR21818; BC025462 PROTEIN; 1.
DR   PANTHER; PTHR21818:SF0; FANCONI ANEMIA GROUP I PROTEIN; 1.
DR   Pfam; PF14679; FANCI_HD1; 1.
DR   Pfam; PF14680; FANCI_HD2; 1.
DR   Pfam; PF14675; FANCI_S1; 1.
DR   Pfam; PF14676; FANCI_S2; 1.
DR   Pfam; PF14677; FANCI_S3; 1.
DR   Pfam; PF14678; FANCI_S4; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          1..101
FT                   /note="FANCI solenoid 1"
FT                   /evidence="ECO:0000259|Pfam:PF14675"
FT   DOMAIN          105..191
FT                   /note="FANCI helical"
FT                   /evidence="ECO:0000259|Pfam:PF14679"
FT   DOMAIN          199..362
FT                   /note="FANCI solenoid 2"
FT                   /evidence="ECO:0000259|Pfam:PF14676"
FT   DOMAIN          376..604
FT                   /note="FANCI helical"
FT                   /evidence="ECO:0000259|Pfam:PF14680"
FT   DOMAIN          622..847
FT                   /note="FANCI solenoid 3"
FT                   /evidence="ECO:0000259|Pfam:PF14677"
FT   DOMAIN          860..1110
FT                   /note="FANCI solenoid 4"
FT                   /evidence="ECO:0000259|Pfam:PF14678"
FT   REGION          1116..1150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          507..538
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1150 AA;  129915 MW;  54B0311736D01B87 CRC64;
     MFKDVPLTAE EVEFVVEKVL RMFGKLNLQE IPPLVYQLLV LSSKGSRRRA LEGIIAFFNE
     LDKRHSEEQS GDELLDLVTV PSGELRHVEG TIILHIVFAV KLDCELGREL LKHLKAGQQG
     DFSNNICPFS IALLLSVTRI QRFEEQVFDL LKALVVKSFK DRQLLQSSKF LQNLVPHRSC
     VSTMILEVVK NSVHSWDHVT QGLVELGFIL MDSYGPKKIL DGKSIETSSG LSKIPNQHAC
     KLGASILLET FKVHEMIRQE ILEQVLNRVV TRASSPISHF LDLLSNIIMY APLVLQSCSS
     KITETFDYFS FLPLQTVQGL LKAVQPLLKV SMSVRDSLIL VLRKAMFASQ LDARKSAVAG
     FLLLLKNFKV LGSLSSSQCS QSVGASQVHV DVHSRYNSVA NETFCLEIMD SLRRCLGQQA
     DVRLMLYEGF YDVLRRNSQL ANSIMQTLLS QLKQFYEPEP DVLPPLKLEA CILTQGDQIS
     LQEPLDHLLC CVQHCLIWYK SRVMPLQQEE EEEEEEFYQE LEDMLESVTS RMIKSELEDF
     ELDKSADFSQ STGVGIKNNI CASLVMGICE VLIEYNFSIS NFSKNKFEEV LSLFMCYKKL
     SDILNEKAGK GKTKTANKME SFWSMKFVSD LLSALFRDST QSHEESLSVL RSSNEFMRHA
     VSAALQKVQQ LKETGHVSGP DGQNPEKVFQ NLCDITRVLL WRYTSIPTSV EDLGKKEKGK
     SISLLCLEGL QKVLSAVSLF YQPKIHQFLR ALDVTDNEGE EAEDSISHRA AFQIRQFQRS
     LLNLLSSQEE DFNSKEALLL VTVLSNLSKL LEPSSPQFVQ MLSWTSKICK ENNHEDPSFC
     KGLMNLLFSL HVLYKSPVTL LRDLSQDIHG HLGDIDQDVE VEKTDHFAMV NLRTAAPTVC
     LLVLSQAEKV LEEVDWLITK LKGQVSQEIV SEEPSSQATH PHHPIEKAII MQLGTLLTFF
     HELVQTALPS GSCVDILLKD LCKMYTILTA LVRYYLQVCQ SARGIPKNME KLVKLSGSHL
     TPLCYSFISY IQNKKSQSLK CTGEKKGKAA VVATAMARAL RETKPIPNLI FAIEQYEKFL
     IHLSKKSKVN LMQHMKLSTS RDFKIKGNIL DVVLRDEEAD EPEEGTASEH EGQNKEPAKK
     KRRKEMKCLS
//