ID A0A2Y9K1I5_ENHLU Unreviewed; 559 AA.
AC A0A2Y9K1I5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=CENPB DNA-binding domain-containing protein 1 {ECO:0000313|RefSeq:XP_022367163.1};
GN Name=LOC111152809 {ECO:0000313|RefSeq:XP_022367163.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022367163.1};
RN [1] {ECO:0000313|RefSeq:XP_022367163.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022367163.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000256|ARBA:ARBA00010881}.
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DR RefSeq; XP_022367163.1; XM_022511455.1.
DR AlphaFoldDB; A0A2Y9K1I5; -.
DR STRING; 391180.A0A2Y9K1I5; -.
DR KEGG; elk:111152809; -.
DR OrthoDB; 2967227at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR19303:SF59; CENPB DNA-BINDING DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR19303; TRANSPOSON; 1.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00320,
KW ECO:0000313|RefSeq:XP_022367163.1};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00320};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 13..64
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DOMAIN 78..157
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000259|PROSITE:PS51253"
FT DNA_BIND 40..60
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 456..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..474
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 63617 MW; D42E488056CAAA51 CRC64;
MPGKRPLNAA VIPHAKRERK AITLDLKLEV LRRFEVGEKL SQIAKALGLA VSTVATIRDN
KEKIKANSQV ATPLRASRLT RHRSAIMETM ERLLHVWLED QSQRNVPLSV TIIQEKAKSL
FDDLQRERGG RSPAEKFSAS KGWFVRFKER HGLPHFTVSS TAPGHKDVYP EVLRSIIEKG
EYSPQQVFNV DETGLYWKRM PEGMFISVEE KAESGFKSSK DRLMLLLGGN AAGDFKLKPL
LVYHLENPKA LKGYSKPNLP VIWRSNKKAW ATRTIFQEWF TYFFCPAIEK YCAQNHLTNK
ALLILDNAPC HPVNLGDLSD NVRVEYLHDR TADLVQPMGQ GVTSIFKAHY MRRTFEHILE
ATDGEDTAMI REFWRNYSIM DAVDNIAVAW EELRRATMNS VWKKIWPECV QFQSVSQTDN
IAQLQENIVT LARNMAFEEV VEADVDRLLR SQEDDLSNEE LMQLEQEPSG EEESEDAAPA
LRQLTTGELS AAFSHFEAGL RVLASNSPGD KWKLQVSRAV SEAINCYREL YREKSSAQSS
SPRSFLRGAT TCLSEESRQ
//
