ID A0A2Y9K1N0_ENHLU Unreviewed; 711 AA.
AC A0A2Y9K1N0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Tensin-4 {ECO:0000313|RefSeq:XP_022365629.1};
GN Name=LOC111151750 {ECO:0000313|RefSeq:XP_022365629.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022365629.1};
RN [1] {ECO:0000313|RefSeq:XP_022365629.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022365629.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
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DR RefSeq; XP_022365629.1; XM_022509921.1.
DR AlphaFoldDB; A0A2Y9K1N0; -.
DR STRING; 391180.A0A2Y9K1N0; -.
DR KEGG; elk:111151750; -.
DR OrthoDB; 3439226at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR CDD; cd01213; PTB_tensin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR033929; Tensin_PTB.
DR PANTHER; PTHR45734; TENSIN; 1.
DR PANTHER; PTHR45734:SF6; TENSIN-4; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 446..553
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 711 AA; 75875 MW; F8D6433804ED89FA CRC64;
MSQVMSSPLL AGGHAVGLTP CEEPRRTLHP APSPGLPPQC PYYTTEGWGA QGLMAPMPFK
GPPSRLQQGP ETGAKASRLL QSPAEQTSGT LEDLNSYIDF SLESLNQMIL ELDPTFQLLP
PGTGSPWTEP TQSTTSRKKK DDAEALDIKY IEVSSTRSRG PDGPQCCSSP SATLPFGSPR
SGGLLLSRDI PRETRSSSES LIFSGSQGRG HQRTPPPSGA PSSHPPPSPS ISIPCMRSKA
SGSHGLGSPL AASPGLEKGL APQRGSRVSV LSASPVSDGS YVFGSSQSLI HSSISSHQSS
SRSLKSPASS SSSLHSLGQV SLCTRASDSQ VPGNPTSNMG QPRTTHSPPA AKEHASSCPP
SITNSMVDIP IVLINGCPEP GSPPTQQIPG HQDFVRPGDT SSSNSCPATR SDSQTLPDAP
LTTPSEGPTR DMQPTMKFVM DTSKYWFKPS ITREQAIELL RKEEPGAFVV RDSSSYRGSF
GLALKVQEAP APAVNRSGED NSDLIRHFLI ESSAKGVHLK GADEEPYFGS LSAFVCQHSI
MALALPCKLT IPQKELGGGV SSDTTDSQAS CLKKSAGCHA LYLTSVSVET LSGALAVRKA
ISTTFERDVL PTPTVVHFKV TDQGITLTDV QRKVFFRRHY PLTTLRFCGM DPEQRKWQKY
CKPSWIFGFV AKSQTESQEN VCHLFAEYDP VQPASQVISL VGALLQDTER M
//
