ID A0A2Y9K2S9_ENHLU Unreviewed; 992 AA.
AC A0A2Y9K2S9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC111153203 {ECO:0000313|RefSeq:XP_022367787.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022367787.1};
RN [1] {ECO:0000313|RefSeq:XP_022367787.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022367787.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
CC -!- SIMILARITY: Belongs to the Arkadia family.
CC {ECO:0000256|ARBA:ARBA00007622}.
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DR RefSeq; XP_022367787.1; XM_022512079.1.
DR AlphaFoldDB; A0A2Y9K2S9; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16681; RING-H2_RNF111; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR029306; RNF111_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16200:SF1; E3 UBIQUITIN-PROTEIN LIGASE PLR-1-RELATED; 1.
DR PANTHER; PTHR16200; RING ZINC FINGER; 1.
DR Pfam; PF15303; RNF111_N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 940..981
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 76..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..530
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..690
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 108872 MW; 0F2F2E2E1811463E CRC64;
MPSLKFLMSQ WTPEYNKLYT LKVDMKSEIP SDAPKTQESL KGILLHPEPI GAAKSFPAGV
EMINSKVGNE FSHLCDDSQK QEKDMNGNQQ EQEKSVVVRK KRKSQQAGPS YMQNCVKENQ
GILGLRQHLE TPSDEDNDSS FSDCLSSPSS SLHFGDSDTV TSDEDKEVSV RHSQAILSAK
SRTHSARSQK WPRTETESVS GLLMKRPCFH SSSLRRLPCR KRFVKNNSSQ RTQKQKERIL
MQRKKREVLA RRKYALLPTS SSSSENDLSS ESSSSSSTEG EEDLFVSTSE NHQNNPTVPS
GSIDEDVVVI EASSTPQVTA NEEINVTSTD SEVEIVTVGE SYRSRSTLGH SRSHWSQGSN
SHTSRPQEPR NRSRISTVIQ PLRQNAAEVV DLTVDEDEPT VVPTTSARME SQTTSTSINN
SNPSTSEQAS DAASAVTGSQ PSIVSETSAT LTSNSMTGTS IGDDSRRTSS SAVTETGPPA
MPRLPSCCPQ HSPCGGSSQN HHALGHPHTS CFQQHGHHFQ HHHHHHHTPH PPVPVSPSFS
DSTCPVERPP QVQAPCGANS SSGTSYHDQQ ALPVDLSNNG IRSHGNGGFH GASAFDPCCP
VSSSRAAIFG HQAAAAAPSQ PLSIDGYGSS MVAQPQPQPP PQASLSSCRH YMPPPYASLT
RPLHHQASAC PHSHGNPPPP TQPPPQVDYV IPHPVHAFHS QISSHATSHP VAPPPPTHLA
STAAPIPQHL PPTHQPISHH IPATAPPAQR LHPHEVMQRM EVQRRRMMQH PTRAHERPPP
HPHRMHPNYG HGHHIHVPQT MSSHPRQAPE RSAWELGIEA GVTAATYTPG ALHPHLAHYH
APPRLHHLQL GALPLMVPDM AGYPHIRYIS SGLDGTSFRG PFRGNFEELI HLEERLGNVN
RGASQGTIER CTYPHKYKKR KLHCKQDGEE GTEEDTEEKC TICLSILEEG EDVRRLPCMH
LFHQVCVDQW LITNKKCPIC RVDIEAQLPS ES
//
