ID A0A2Y9K3C8_ENHLU Unreviewed; 2856 AA.
AC A0A2Y9K3C8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Lipopolysaccharide-responsive and beige-like anchor protein {ECO:0000313|RefSeq:XP_022368012.1};
GN Name=LOC111153330 {ECO:0000313|RefSeq:XP_022368012.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022368012.1};
RN [1] {ECO:0000313|RefSeq:XP_022368012.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022368012.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022368012.1; XM_022512304.1.
DR STRING; 391180.A0A2Y9K3C8; -.
DR KEGG; elk:111153330; -.
DR OrthoDB; 5478899at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2066..2174
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2193..2482
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2768..2809
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1264..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1761..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2856 AA; 317826 MW; 544D0D94C772AF92 CRC64;
MASEDNNVPS PPPTGDDGGG GGKEETSAEE GALSLKPGLP IRGIRMKFAV LTGLVEVGEV
SNRDIVETVF NLLVGGQFDL EMNFIIQEGE SIICMVDLLE KCDITCQAEV WSMFTAILKK
SIRNLQVCTE VGLVEKVLGK IEKVDNMIAD LLVDMLGVLA SYNLTVRELK LFFSKLQGHK
GQWPPHAGKL LSVLKHMPQK YGPDAFFNFP GKSAAAIALP PIAKWPYQNG FTFHTWLRMD
PVNNINVDKD KPYLYCFRTS KGLGYSAHFV GGCLIITSIK SKGKGFQHCV KFDFKPQKWY
MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET ADANRVFCGQ
MTAVYLFSEA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL AEHHKLLLYD GKLSSAIAFT
YNPRATDAQL CLESSPKDNP SIFVHSPHAL MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF
AQLDYRQYLS DEVDVTICST LLAFILELLK NSVAMQEQML ACKGFLVIGY SLEKSSKSHV
SRAVLELCLA FSKYLSNLQN GMPLLKQLCD HILLNPAIWI HTPAKVQLTL YTYLSTEFIG
TVNIYNAIRR VGTVLLITHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE ILSLRAFLLM
FIKQLVMKDS GVKEDELQAI LNYLLTMHED DNLMDVLQLL VALMSEHPNS MIPAFDQRNG
LRVIYKLMAS TSEGIRVQAL KAMGYFLKHL APKRKAEVML GHGLFSLLAE RLMLQTNLIT
MTTYNVLFEI LIEHICTQVI HKQHPDPDSS VKIQNPQILK VIATLLRNSP QCPESMEVRR
AFLSDMIKLF NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH
AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLASMFREHQ GKVDEEIGQC SSSVEAVSAI
SRDVNVSIAS QQSDMKACPV SPHITRNSDE KSPVEKTISV DCASTAELQT PNTSNEERKT
GQESQELLDE VPSEETLINE TINTGDLEVS SDMIEAEAET VSSNSFKMIG KGIMTVSEVT
ASISSPSEED ASEVPELLDK SIGEEDDDDY VELKVENSPT EEASLPTELQ DDSLSPAASE
ASERLDMLSN DNKLIFQEQE SVNKKQIDSE TQDSKDSGIL TMTASGSSAT SPDTTVSQTP
VQSDIGEMLE EGKKKTNFVR ETKLIGDSPV FESPTTSEQR IAKLDVSSVA TDTERLELKA
STNMEASQPH QPMPEMSRRQ EEPSQGMAPV GVNGQRRDSR SAMFRIPEFK WSQMHQRLLT
DLLFSIETDI QMWRSHSTKT VMDFVNSSDN VIFVHNTIHL ISQVMDNMVM ACGGILPLLS
AATSATHELE NIEPTQGLSI EASVTFLQRL ISLVDVLIFA SSLGFTEIEA EKSMSSGGIL
RQCLRLVCAV AVRNCLECQQ HSQLKARGDT AKGQKIMHSL IPMGKSAAKS PVDIVTGGIS
PVRDFDKLLQ DMDINRLRAV VFRDIEDSKQ AQFLALAVVY FISVLMVSKY RDILEPQNER
HNQSFKGTGN ERGNSSLPDV ENTPSAFSPL TPASVEESES TSSARRRDSG VGEESAAGLA
NSVDVAPPSA PPSVSAGPDA VSEALCTLSL EVNKSQETKN DGGNELANKA APSVPVSKNV
NVKDILRSLV NIPADGVTVD PALLPPACLG ALGDLSVEQP VQFRSFDRSV IIATKKSAVL
PSTLTASLPT NAVSVVSSVD SSQASDVGGD SPGGRSSNAK LPSVPTVGSV PQDQVSNMSI
TERLEHALEK AAPLLREIFV DFAPFLSRTL LGSHGQELLI EGTSLVCMKS SSSVVELVML
LCSQEWQNSI QKNAGLAFIE LVNEGRLLSQ TMKDHLVRVA NEAEFILSRQ RAEDIHRHAE
FESLCAQYSA DKREDEKMCD HLIRAAKYRD HVTATQLIQK IINILTDKHG AWGNSAVSRP
REFWRLDYWE DDLRRRRRFV RNPLGSTHPE ATLKTAVEHA ADEDILAKGK QSIKSQALGN
QNSENEILLE GDDDTLSSVD EKDLENLAGP VSLSTPAQLV APSVVVKGTL SVTSSELYFE
VDEEDSHFKK IDPKILAYTE GLHGKWLFTE IRSIFSRRYL LQNTALEIFM ANRVAVMFNF
PDPATVKKVV NYLPRVGIGT SFGLPQTRRI SLASPRQLFK ASNMTQRWQH REISNFEYLM
FLNTIAGRSY NDLNQYPVFP WVITNYESEE LDLTLPSNFR DLSKPIGALN PKRAAFFAER
YESWEDDQVP KFHYGTHYST ASFVLAWLLR IEPFTTYFLN LQGGKFDHAD RTFSSISRAW
RNCQRDTSDI KELIPEFYYL PEMFVNFNNY NLGVMDDGTV VSDVELPPWA KTSEEFVRIN
RLALESEFVS CQLHQWIDLI FGYKQLGPEA VRSLNVFYYL TYEGAVNLNS IADPVLREAV
EAQIRSFGQT PSQLLIEPHP PRGSAMQVSP LMFTDQAQQD VIMVLKFPSN SPVTHVAANT
QPGLATPAVI TVTANRLFAV NKWHNLPAHQ GAVQDQPYQL PVEIDPLIAS NTGMHRRQIT
DLLDQSIQVH SQCFVITSDN RYILICGFWD KSFRVYSTDT GKLIQVVFGH WDVVTCLTRS
ESYIGGNCYI LSGSRDATLL LWYWNGKSSG IGDNPGSETT TPRAILTGHD CEITCAAVCA
ELGLVLSGSK EGPCLIHSMN GDLLRTLEGP ENCLKPKLIQ ASREGHCVIF YENGCFCTFS
VNGKLQATME TDDNIRAIQL SRDGQYLLTG GDNGVVMVWQ VSDLKHLFAY PGCDAGIRAM
ALSHDQRCII SGMASGSIVL FYNDFNRWHH EYQTRY
//