ID   A0A2Y9K4H3_ENHLU        Unreviewed;       947 AA.
AC   A0A2Y9K4H3;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Potassium voltage-gated channel subfamily KQT member 5 isoform X3 {ECO:0000313|RefSeq:XP_022366559.1};
GN   Name=LOC111152345 {ECO:0000313|RefSeq:XP_022366559.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022366559.1};
RN   [1] {ECO:0000313|RefSeq:XP_022366559.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022366559.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022366559.1; XM_022510851.1.
DR   AlphaFoldDB; A0A2Y9K4H3; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 6.10.140.1910; -; 2.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR   PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        206..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          132..361
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          462..649
FT                   /note="Potassium channel voltage dependent KCNQ C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03520"
FT   REGION          435..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          767..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          890..947
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..934
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   947 AA;  103933 MW;  687C0E1D8A8D030D CRC64;
     MPRHHAGGEE GGAAGLWVKS GAAAAAAAAG GGRLGSGMKD VESGRGRVLL NSAAARGDGL
     LLLGTRAAAL GGGGGSGGGL KESRRGKQGA RMSLLGKPLS YTSSQSCRRN VKYRRVQNYL
     YNVLERPRGW AFIYHAFVFL LVFGCLILSV FSTIPEHTKL ASSCLLILEF VMIVVFGLEF
     IIRIWSAGCC CRYRGWQGRL RFARKPFCVI DTIVLIASIA VVSAKTQGNI FATSALRSLR
     FLQILRMVRM DRRGGTWKLL GSVVYAHSKE LITAWYIGFL VLIFSSFLVY LVEKDANKEF
     STYADALWWG TITLTTIGYG DKTPLTWLGR LLSAGFALLG ISFFALPAGI LGSGFALKVQ
     EQHRQKHFEK RRNPAANLIQ CVWRSYAADE KSVSIATWKP HLKALHTCSP TNKFCSNKQK
     LFRMYTSRKQ SQKLSFKERV RMASPRGQSI KSRQASVGDR RSPSTDITAE GSPTKVQKSW
     SFNDRTRFRP SLRLKSSQPK PVIDADTALG TDDVYDEKGC QCDVSVEDLT PPLKTVIRAI
     RIMKFHVAKR KFKETLRPYD VKDVIEQYSA GHLDMLCRIK SLQTRVDQIL GKGQITSDKK
     SREKITAEHE TPDDLSMLGR VVKVEKQVQS IESKLDCLLD IYQQVLRKGS ASALTLASFQ
     IPPFECEQTS DYQSPVDSKD LSSSAQNSGC LSRSASANIS RGLQFILTPN EFSAQTFYAL
     SPTMHSQATQ VPMSQSDGCA AAAASNLANQ ISVAPKPAAP TTLQIPPPLP AIKHLPRPET
     LHPNPAGLQE SISDVTTCLV ASKENVQVAQ SNLTKDRSLR KSFDMGGETL LSVRPAVPKD
     LGKSLSVQNL IRSTEELNIQ LSGSDSSGSR GSQDFYPKWR ESKLFITDEE VGPEETETDT
     FDAMPQPARE TAFASDSLRT GRSRSSQSIC KAGESTEALS LPHVKLK
//