ID A0A2Y9K515_ENHLU Unreviewed; 2346 AA.
AC A0A2Y9K515;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Voltage-dependent T-type calcium channel subunit alpha-1G isoform X2 {ECO:0000313|RefSeq:XP_022364750.1};
GN Name=LOC111151233 {ECO:0000313|RefSeq:XP_022364750.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022364750.1};
RN [1] {ECO:0000313|RefSeq:XP_022364750.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022364750.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022364750.1; XM_022509042.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF137; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1254..1272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1292..1313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1325..1344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1389..1411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1491..1514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1578..1599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1611..1634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1712..1731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1795..1817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..405
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 743..972
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1252..1524
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1577..1827
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2148..2183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1523..1557
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 470..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..509
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1126..1150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2283..2299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2346 AA; 259621 MW; 205AB38159C7E4B3 CRC64;
MDEEEDGAGT EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV
FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF
DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR
TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR
CFLPENFSLP LSVDLERYYQ TENEDENPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCGL
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM
YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA
STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAVGV RAGLLSGPVP RSSQEPQPGG
SCSRSHRRPS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDASGSR RLMLPPPSTP
ALSGGPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEES GRTVGSGKVY PTVHTSPPPE
TLKERALVEV APTSGPPTLT SLNIPAGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG
ACGPDSCPYC ARAGAGPVEL AGHEMPDSDS EVVYELTQDA QHSDVRDPHS RQRQSLGLDV
EPNSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI
VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR
VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV
AILVEGFQAE GDATKSESEP DFFSPSLDGN GDRKKRLALV SLGDPPELRR NLLPPLIIHT
AATPMSLPKS SSTGLAEVPG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW
TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGRESQDEE ESSEEERTSP AGSDRRHGGS
LEREAKNSFD LPDTLRVPAL HRTASGRSSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD
GDDEGNLSRG ERIRVWIRAR LPACCRERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL
VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR
SSWNVLDGLL VLISIIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE
TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV
RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPVMNHNPWM LLYFISFLLI
VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRSKEKQ MAEAQCKPYY
SDYSRFRLLV HHLCTSHYLD LFITGVIGLN VVTMAMEHYQ QPQILDEALK ICNYIFTVIF
VLESVFKLVA FGFRRFFQDR WNQLDLAIVL LSIMGITLEE IEVNASLPIN PTIIRIMRVL
RIARVLKLLK MAVGMRALLD TVMQALPQVG NLGLLFMLLF FIFAALGVEL FGDLECDETH
PCEGLGRHAT FRNFGMAFLT LFRVSTGDNW NGIMKDTLRD CDQESTCYNT VISPIYFVSF
VLTAQFVLVN VVIAVLMKHL EESNKEAKEE AELEAELELE MKTLSPQPHS PLGSPFLWPG
VEGPDSPNSP KPGAPHTVAH AGEASRFSLE HPTDRQLFDT ISLLIQGSLE GELKLMDELA
GPGGQPSAFP PVRSPGGSDP QIPLAEMEAL SLTSEIVSEP SCSLALTDDS LPDDTHTLLL
SVLESNMEPH PEGMPLTLGP DLLTVRKSGV SRTHSLPNDS YMCRDGRTAE GSLGHRSWGL
PKAQSGSVLS VHSQPADTSY ILQLPKDTPH LLQPHGAPTW GTIPKLPPPG RSPLAQRPLR
RQAAIRTDSL DVQGLGSRDD LLSEGSGPSL PLVRASSFWG HLGSRIQQHP RRQSKISKHM
PLPAPCPGSE PTWSKGPPDT RSSLELDTEL SWISGDLLTV GSPEEPPSPR DLKKCYSVEA
QSCRRRPASW LDEQRRHSIA VSCLDSGSQP SLGPDPSSLG GQPLGGPGSR PKKKLSPPSI
SIDPPENQGP RPPPSPGVCL RRRAPSSDSK DPSASGPPDS MAASPPPKID VLSLSGLASD
PADLAP
//
