ID A0A2Y9K9F1_ENHLU Unreviewed; 747 AA.
AC A0A2Y9K9F1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Transducin-like enhancer protein 4 isoform X10 {ECO:0000313|RefSeq:XP_022368224.1};
GN Name=LOC111153482 {ECO:0000313|RefSeq:XP_022368224.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022368224.1};
RN [1] {ECO:0000313|RefSeq:XP_022368224.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022368224.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR RefSeq; XP_022368224.1; XM_022512516.1.
DR AlphaFoldDB; A0A2Y9K9F1; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 22..112
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 547..588
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 589..630
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 671..702
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 108..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 30..57
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 156..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 80889 MW; 93A4CDDCAA63BA00 CRC64;
MARVPPTGQF RFRAPHQPAQ PFKFTISESC DRIKEEFQFL QAQYHSLKLE CEKLASEKTE
MQRHYVMYYE MSYGLNIEMH KQAEIVKRLN AICAQVIPFL SQEQQQLQAQ HLSHGHGLPV
PLTPHPSGLQ PPAIPPIGSS AGLLALSSAL GGQSHLPIKD EKKHHDNDHQ RDRDSIKSSS
VSPSASFRGA EKHRNSTDYS SDSKKQKTEE KEIAARYDSD GEKSDDNLVV DVSNEDPSSP
RGSPAHSPRE NGLDKTRLLK KDAPISPASI ASSSSTPSSK SKELSLNEKS TTPVSKSNTP
TPRTDAPTPG SNSTPGLRPV PGKPPGVDPL ASSLRTPMAV PCPYPTPFGI VPHAGMNGEL
TSPGAAYAGL HNISPQMSAA AAAAAAAAAY GRSPVVGFDP HHHMRVPAIP PNLTGIPGGK
PAYSFHVTAD GQMQPVPFPP DALIGPGIPR HARQINTLNH GEVVCAVTIS NPTRHVYTGG
KGCVKVWDIS HPSNKSPVSQ LDCLNRDNYI RSCRLLPDGR TLIVGGEAST LSIWDLAAPT
PRIKAELTSS APACYALAIS PDSKVCFSCC SDGNIAVWDL HNQTLVRQFQ GHTDGASCID
ISNDGTKLWT GGLDNTVRSW DLREGRQLQQ HDFTSQIFSL GYCPTGEWLA VGMENSNVEV
LHVTKPDKYQ LHLHESCVLS LKFAHCGKWF VSTGKDNLLN AWRTPYGASI FQSKESSSVL
SCDISVDDKY IVTGSGDKKA TVYEVIY
//
