ID A0A2Y9KAU9_ENHLU Unreviewed; 1516 AA.
AC A0A2Y9KAU9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=DNA topoisomerase 2-binding protein 1 isoform X1 {ECO:0000313|RefSeq:XP_022370847.1};
GN Name=LOC111155090 {ECO:0000313|RefSeq:XP_022370847.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022370847.1};
RN [1] {ECO:0000313|RefSeq:XP_022370847.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022370847.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_022370847.1; XM_022515139.1.
DR STRING; 391180.A0A2Y9KAU9; -.
DR KEGG; elk:111155090; -.
DR OrthoDB; 449768at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR CDD; cd17737; BRCT_TopBP1_rpt1; 1.
DR CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR CDD; cd17718; BRCT_TopBP1_rpt3; 1.
DR CDD; cd17749; BRCT_TopBP1_rpt4; 1.
DR CDD; cd18434; BRCT_TopBP1_rpt5; 1.
DR CDD; cd17727; BRCT_TopBP1_rpt6; 1.
DR CDD; cd17738; BRCT_TopBP1_rpt7; 1.
DR CDD; cd17728; BRCT_TopBP1_rpt8; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 9.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035960; Secretoglobin_sf.
DR InterPro; IPR044737; TopBP1_BRCT_1.
DR PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 5.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR Pfam; PF21298; TopBP1_BRCT0; 1.
DR SMART; SM00292; BRCT; 8.
DR SUPFAM; SSF52113; BRCT domain; 6.
DR SUPFAM; SSF48201; Uteroglobin-like; 1.
DR PROSITE; PS50172; BRCT; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 101..172
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 195..284
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 359..449
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 543..628
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 636..733
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 895..986
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1253..1345
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 737..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1516 AA; 169687 MW; 0E96CD18E60882AC CRC64;
MSRNDKEPFL VKFLKSSDNS ECFFKALESI KEFQSEEYLQ IITEEEALEI KENDRSLYIC
DPFSGIVFDH LKKLGCRIVG PQVVIFCMHH QRCVPRAEHP VYNMVMSDVT VSCTSLEKDK
REEVHKYVQM MGGRVYRDLN ISVTHLIAGE VGSKKYLVAA NLKKPILLPS WIKTLWEKSQ
EKKIARYTDV NMEDFKCPIF LGCIICVTGL CSLDRKAVQQ LTVKHGGQYM GQLKMNECTH
LIVQEPKGQK YECAKRWNVH CVTTQWFFDS VDKGFCQDES IYKTEPRSET KTVPDTSTPT
GQINTVDSKF QCRTLSDVSH ISNINASCIN ESMCNSVLNS KVEPTLENLE NLDVSAFQAP
EDLLDGCRIY LCGFSGRKLD KLRRLINSGG GVRFNQLNED VTHVIVGDHD DELKQFWDKS
AHRPHVVGAK WLLECFSKGY MLPEEPYIHA NYQPVEIPVS DQPESKTALL KRNNSLSKKN
LAPDEKHEQA DEDLLSQYIN NNPTVVEAVK SEVEPFNDST HISLPEENQS SVTCCLPDTS
TITEEGLFSQ KTFLVLGFSN ENESNIANII RENAGKIVSL QSRIVADYAV VPLLGCEVEA
TVGEVVTNTW LVTCIDYQTL IDPKSNPLFM PVPVMAGMTP LEDCVISFSQ CVGAEKDSLT
FLANRLGASV QEFFVRKSNA KKGMFASTHL VLKEPGGSKY EAAKKWNLPA VTISWLLETA
RMGKRADESH FLIEKSAKEE QSVETETTNR VNLNPGTPEH PVAHLETHRK TAVTPLDMNC
FQSKAFHAVI SQHTRQVSAS PPVGQPLQKE PSLHLDTPSK FLSKDKLFKP SFDVKDALAA
LETPGGPSQQ KRKLSTPLSE VIVRNLKLAL ANSSRNAVAL SASPQLKDAQ SKKEEAPKPL
HKVVVCVSKK LSKKQGELNG IAASLGADYR WSFDETVTHF IYQGRPNDTN REYKSVKERG
VHIVSEHWLL ECAQEYKHLP ESLYPHTYNP KMSLDISTVQ DGRLSNSRLL SVDSATKDDE
PDHLPVEEND IDSVATSNKE SGISNGGGRS DSKGALTQTL EMRENFQKQL QEIMSATSIV
KPQGQRASLS RSGCNSASST PDSTRSARSG RSRVLEALRQ SRQTVPDVNT EPSQNEQIIW
DDPTAREERA RLASSLQWPS CPTQYSELQV DIKKLEDSPS QEALRDSEIA EQAVCDPGNV
CVTEAPKPQI SEELETPVKD SHLIPTPQAP SIAFPLANPP VAPHPREIIT IEETHEDLKK
QYIFQLSSLN PQERIDYCHL IEKLGGLVIE KQCFDPNCTH IVVGHPLRNE KYLASVAAGK
WVLHRSYLEA CRTAGHFVPE EDYEWGSSSI LDVLTGINVQ QRRLALAAMR WRKKLQQRQE
SGIVEGAFSG WKVILYVDQS REAGFKRLLQ SGGAKVLPGY SVPLFKEATH LFSDFNKLKP
DDSGVNIAEA AAQNVYCLKT EYIADYLMQE SPPRVENYCL PEAISFLPNN KEPGPGLSQK
RKAPTEKNKM KRPRVN
//