UniProt: A0A2Y9KBM8

Database: UniProt
Entry: A0A2Y9KBM8_ENHLU

LinkDB:  A0A2Y9KBM8_ENHLU 
Original site:  A0A2Y9KBM8_ENHLU

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Ontology (17)   
   GO (17)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (7)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (2)   
   SMART (1)   
All databases (26)   

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ID   A0A2Y9KBM8_ENHLU        Unreviewed;       191 AA.
AC   A0A2Y9KBM8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Calcium and integrin-binding protein 1 {ECO:0000256|ARBA:ARBA00040936};
DE   AltName: Full=Calmyrin {ECO:0000256|ARBA:ARBA00041782};
GN   Name=LOC111152604 {ECO:0000313|RefSeq:XP_022366830.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022366830.1};
RN   [1] {ECO:0000313|RefSeq:XP_022366830.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022366830.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004221}. Cell membrane, sarcolemma
CC       {ECO:0000256|ARBA:ARBA00004135}. Cell projection, filopodium tip
CC       {ECO:0000256|ARBA:ARBA00004495}. Cell projection, growth cone
CC       {ECO:0000256|ARBA:ARBA00004624}. Cell projection, lamellipodium
CC       {ECO:0000256|ARBA:ARBA00004510}. Cell projection, neuron projection
CC       {ECO:0000256|ARBA:ARBA00004487}. Cell projection, ruffle membrane
CC       {ECO:0000256|ARBA:ARBA00004632}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004635}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Perikaryon
CC       {ECO:0000256|ARBA:ARBA00004484}.
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DR   RefSeq; XP_022366830.1; XM_022511122.1.
DR   AlphaFoldDB; A0A2Y9KBM8; -.
DR   STRING; 391180.A0A2Y9KBM8; -.
DR   KEGG; elk:111152604; -.
DR   OrthoDB; 5472814at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR45791; CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2; 1.
DR   PANTHER; PTHR45791:SF3; CALCIUM AND INTEGRIN-BINDING PROTEIN 1; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00022618};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Integrin {ECO:0000313|RefSeq:XP_022366830.1};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT   DOMAIN          103..138
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          148..183
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
SQ   SEQUENCE   191 AA;  21773 MW;  D25F823CE9BB93AD CRC64;
     MGSSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPP EHRSVEESLQ IRVSLEQILS
     LPELKANPFK ERICRIFSTS PARDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD
     GTLNREDLSH LVNCLTGQGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS
     PDFASSFKIV L
//

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