UniProt: A0A2Y9KBQ9

Database: UniProt
Entry: A0A2Y9KBQ9_ENHLU

LinkDB:  A0A2Y9KBQ9_ENHLU 
Original site:  A0A2Y9KBQ9_ENHLU

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Ontology (5)   
   GO (5)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (14)   
   InterPro (8)   
   Pfam (2)   
   PROSITE (2)   
   SMART (2)   
All databases (21)   

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ID   A0A2Y9KBQ9_ENHLU        Unreviewed;       435 AA.
AC   A0A2Y9KBQ9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=General transcription factor IIH subunit {ECO:0000256|PIRNR:PIRNR015919};
GN   Name=LOC111155330 {ECO:0000313|RefSeq:XP_022371182.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022371182.1};
RN   [1] {ECO:0000313|RefSeq:XP_022371182.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022371182.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR015919}.
CC   -!- SIMILARITY: Belongs to the GTF2H2 family.
CC       {ECO:0000256|ARBA:ARBA00006092, ECO:0000256|PIRNR:PIRNR015919}.
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DR   RefSeq; XP_022371182.1; XM_022515474.1.
DR   AlphaFoldDB; A0A2Y9KBQ9; -.
DR   STRING; 391180.A0A2Y9KBQ9; -.
DR   KEGG; elk:111155330; -.
DR   OrthoDB; 276422at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   CDD; cd01453; vWA_transcription_factor_IIH_type; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR007198; Ssl1-like.
DR   InterPro; IPR004595; TFIIH_C1-like_dom.
DR   InterPro; IPR012170; TFIIH_SSL1/p44.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   NCBIfam; TIGR00622; ssl1; 1.
DR   PANTHER; PTHR12695; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2; 1.
DR   PANTHER; PTHR12695:SF2; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED; 1.
DR   Pfam; PF07975; C1_4; 1.
DR   Pfam; PF04056; Ssl1; 1.
DR   PIRSF; PIRSF015919; TFIIH_SSL1; 1.
DR   SMART; SM01047; C1_4; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR015919};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015919};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          100..276
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   ZN_FING         331..348
FT                   /note="C4-type"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015919-1"
SQ   SEQUENCE   435 AA;  49230 MW;  81CF39CD2D645B78 CRC64;
     MFTSLSLLFT FKCMNLVPNI LRKFTLSGFY RILNNTLKEK MDEEPERTKR WEGGYERTWE
     ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR
     LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKKAVDMTCH
     GEPSLYNSLS MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK AAKIRVSVIG
     LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHVSPPP ASSSSECSLI RMGFPQHTIA
     SLSDQDAKPS FSMAHLDSNT EPGLTLGGYF CPQCRAKYCE LPVECKICGL TLVSAPHLAR
     SYHHLFPLDA FQEIPLEEHN GEKFCYGCQG ELKDQHVYVC AVCQNVFCVD CDVFVHDSLH
     CCPGCIHKIP TSSNI
//

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