ID A0A2Y9KC91_ENHLU Unreviewed; 1177 AA.
AC A0A2Y9KC91;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Mucin-4 {ECO:0000313|RefSeq:XP_022370753.1};
GN Name=LOC111155031 {ECO:0000313|RefSeq:XP_022370753.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022370753.1};
RN [1] {ECO:0000313|RefSeq:XP_022370753.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022370753.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_022370753.1; XM_022515045.1.
DR AlphaFoldDB; A0A2Y9KC91; -.
DR STRING; 391180.A0A2Y9KC91; -.
DR KEGG; elk:111155031; -.
DR OrthoDB; 2911509at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR InterPro; IPR005533; AMOP_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR13802; MUCIN 4-RELATED; 1.
DR PANTHER; PTHR13802:SF65; MUCIN-4; 1.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00723; AMOP; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00216; VWD; 1.
DR PROSITE; PS50856; AMOP; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1177
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015959466"
FT TRANSMEM 1136..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 160..315
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 316..432
FT /note="AMOP"
FT /evidence="ECO:0000259|PROSITE:PS50856"
FT DOMAIN 444..644
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 881..920
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1089..1128
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 37..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 910..919
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1177 AA; 133369 MW; BF431BE75A7FABD7 CRC64;
MKGAQWRRVP WVFLSCLCFC LLWPMILGTI TTSMRIGSQR RTTPSPSTTS QTHTTLSPRT
SIGTHSTPAP VPIKPKKGVP LFPYGPSAGD LEFVKRISDF TSPLFKPQIG FPLGFSLRDY
LYFTDNGQII FPESEYQVFS YPNPPRRGFT GWDPVALVAP FWDDADFSSG QGTIFYQEYE
TLYNEHNLLV WQVESWIRKF TYTWNYKARW TLKVTWVKAP AYPARWTFGT NTYQAILSTD
GSRSYALFLY QNGGMQWDVT QRPGNPVLMG FSSGDGRFEN SPLTSQPLWQ KYLPDQFLNS
NSGARGLQVY SLHGEERPNY RLQCLQWLKR QPWGPTWGWN QISCPCSWQQ GLWDLRFQPI
SMGWWGLGGG SHLCSFSSWR GGVCCHYGPW GELLQGWTVH APWQFDQELE PWDWCCRWND
KPSFCALYHQ RRPRIGCAGY QPPRPAWMFG DPHISTLDGV NFTFNGLGDF QLVRAWDGNS
SFLLQGRTAQ TRSAQATNFI AFAAKYDTSQ LNPITVRWLL KPDDTIHVQV NNQTVTFETN
HEDPEGREMF NTTGIIVTRN GSLVSAIFDG TVTISVIALS NILHASCGLP EAYRNRTEGL
LGVWNDNPDD DFRMPNGSTI PRDSTEELLF QYGMTWEISD TRLLGKRDDH LPSNFIPVFF
SQWRNESLDD KLVSMCDGDK QCIYDSLATG NTSTGLSTKM LFRKYQKMNT TLNKYPPFIT
GQHVLEAHMG QTTRVQYTSH SKSVIFTLRN SSTDFRIFEN GTLLWTPKSL EPFALEILAR
NVEDNLSSVL QPKTVVCACR NESQCVYNLT SRLGGSSLEV AGCKCDRNTF GHYCEHSKNL
CEEPCFESVR CIPGKGCEAC PPHLTGDGRH CAALETSPLC QNKSCPVNYC YNQGHCYVSQ
ALGCQPVCTC PPAFTDTRCF MAGNNFTPTL HQDLPLRIIQ LWVSEEENAS VTDVNASVAY
RLRNLNVRAF LRNSEVVPSD SETAPASGSL LRRWRVISEF QYLPQGPVID FLNTQLLEAV
VVAFLPQASW RRWNRSKGPR TDVNFHPLSR EDVKSLLALN VSVLKNYFNC SGYKDYKLVY
SPQSGLTCVS PCSDGYCEHG GQCQHLPQGP RCTCVPFSIY TPWGERCEHL GMKLGAFFGI
LFGALGFLLL LEAVVFVVLR FWCYGRHHYS YPLDSES
//
