ID A0A2Y9KCN6_ENHLU Unreviewed; 447 AA.
AC A0A2Y9KCN6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Differentially expressed in FDCP 8 homolog isoform X7 {ECO:0000313|RefSeq:XP_022367170.1};
GN Name=LOC111152810 {ECO:0000313|RefSeq:XP_022367170.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022367170.1};
RN [1] {ECO:0000313|RefSeq:XP_022367170.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022367170.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
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DR RefSeq; XP_022367170.1; XM_022511462.1.
DR AlphaFoldDB; A0A2Y9KCN6; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; RH_dom.
DR PANTHER; PTHR12326:SF3; DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG; 1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01175; DUF4206; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 166..217
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 51830 MW; BCD4EBDB82D21BAA CRC64;
MASVSSPVLT QVLGSATSPP RRLNRWDAME YDEKLARFRQ AHLNPFNKEL GPRQHEQRAS
KEAPEVTSEE ALPELPPGEP EFCCTERVMD LGLSEDHFSR PVGLFLASDI EQLRQAIEEC
KQTILELPEQ SEKQKDAVVR LIHLRLKLQE LKDPNEDEPN IRVLLEHRFY KEKGKSVKQT
CDKCNTIIWG LLQTWYTCTG CYYRCHSKCL NLISKPCVRS KVSHQAEYEL NICPETGLDS
QDYRCAECRA PISLRGVPSE ARQCDYTGQY YCTHCHWNDL AVIPARVVHN WDFEPRKVSR
CSMRYLALMA SRPVLRLREI NPLLFNYVEE LVEIRKLRQD ILLMKPYFIT CREAMEARLL
LQLQDRQHFV ENDEMYSVQD LLDAHTGRLS CSLTETHTLF AKHIKLDCER CQAKGFVCEL
CREGDVLFPF DSHTSVCTDC SAVFHRI
//
