ID   A0A2Y9KCS6_ENHLU        Unreviewed;       492 AA.
AC   A0A2Y9KCS6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Heat shock factor protein 4 isoform X1 {ECO:0000313|RefSeq:XP_022367205.1};
GN   Name=LOC111152830 {ECO:0000313|RefSeq:XP_022367205.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022367205.1};
RN   [1] {ECO:0000313|RefSeq:XP_022367205.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022367205.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC       ECO:0000256|RuleBase:RU004020}.
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DR   RefSeq; XP_022367205.1; XM_022511497.1.
DR   AlphaFoldDB; A0A2Y9KCS6; -.
DR   STRING; 391180.A0A2Y9KCS6; -.
DR   KEGG; elk:111152830; -.
DR   OrthoDB; 1117127at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000232; HSF_DNA-bd.
DR   InterPro; IPR027725; HSF_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10015:SF213; HEAT SHOCK FACTOR PROTEIN 4; 1.
DR   PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00447; HSF_DNA-bind; 1.
DR   PRINTS; PR00056; HSFDOMAIN.
DR   SMART; SM00415; HSF; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00434; HSF_DOMAIN; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Stress response {ECO:0000313|RefSeq:XP_022367205.1}.
FT   DOMAIN          59..83
FT                   /note="HSF-type DNA-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00434"
FT   REGION          262..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          338..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  53127 MW;  7B673BA207CDE759 CRC64;
     MQEAPAALPT EPGPNPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD QSRFAKEVLP
     QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE FQHPSFVRGR EQLLERVRRK
     VPALRSDDGR WRPEDLGRLL GEVQALRGVQ ESTEARLREL RQQNEILWRE VVTLRQSHGQ
     QHRVIGKLIQ CLFGPLQTGS SSTGAKRKLS LMLEEGSSCP TPAKFSACPL PGALLQDPYC
     IQSPLPETAL GLSSSHRARG PIISDIHEDS PSPDGTRLSP SRSGRREKGL ALLKEEPASP
     GGEGEAGLAL APNECDFCVT APPPLPVAVV QAILEGKGNF SPEGPRNAQQ PEPRGPREVP
     DRGTLGLERG VRSPEHLLPP MLLQPPTESV EPAGPLDVLG PSHQGREWTL MDLDMELSLM
     QPLGPERSET ELAVKGLNSP GPGKDSTLGA PLLLDVQAAL GGPTLGLPGA LTIYSTPESR
     ASYLGPGANP SP
//