ID   A0A2Y9KDZ6_ENHLU        Unreviewed;       309 AA.
AC   A0A2Y9KDZ6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Polycomb complex protein BMI-1 {ECO:0000256|ARBA:ARBA00039211};
DE   AltName: Full=Polycomb group RING finger protein 4 {ECO:0000256|ARBA:ARBA00042731};
GN   Name=LOC111155498 {ECO:0000313|RefSeq:XP_022371368.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022371368.1};
RN   [1] {ECO:0000313|RefSeq:XP_022371368.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022371368.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_022371368.1; XM_022515660.1.
DR   AlphaFoldDB; A0A2Y9KDZ6; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0031519; C:PcG protein complex; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd17165; RAWUL_PCGF4; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR032443; RAWUL.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR10825:SF21; POLYCOMB COMPLEX PROTEIN BMI-1; 1.
DR   PANTHER; PTHR10825; RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT; 1.
DR   Pfam; PF16207; RAWUL; 1.
DR   Pfam; PF13923; zf-C3HC4_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          18..57
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          217..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  34866 MW;  D383697DE4079F96 CRC64;
     MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV
     HKTRPLLNIR SDKTLQDIVY KLVPGLFKTA NGSNEDRGEV ADEDKRIITD DEIISLSIEF
     FDQNRLDRKV NKDKEKAKEE VNDKRYLRCP AAMTVMHLRK FLRSKMDIPN TFQIDVMYEE
     EPLKDYYTLM DIAYIYTWRR NGPLPLKYRV RPTCKRMKMS HQRDGLTNAG ELESDSGSDK
     ANSPAGGAPS TSSCLPSPST PVQSPHPQFP HISSTMNGTS SSPSGNHQSS FANRPRKSSV
     NGSSATSSG
//