ID A0A2Y9KEC5_ENHLU Unreviewed; 1246 AA.
AC A0A2Y9KEC5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Partitioning defective 3 homolog isoform X8 {ECO:0000313|RefSeq:XP_022371503.1};
GN Name=LOC111155563 {ECO:0000313|RefSeq:XP_022371503.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022371503.1};
RN [1] {ECO:0000313|RefSeq:XP_022371503.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022371503.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR RefSeq; XP_022371503.1; XM_022515795.1.
DR AlphaFoldDB; A0A2Y9KEC5; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 227..303
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 418..503
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 534..609
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 81..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1020..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 138588 MW; 6BC4DF75AC3D3528 CRC64;
MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD
LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ
ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSASISDNNF SSEEPSRKNP TRWSTTAGFL
KQNTAGSPKT CDRKDEDGTE EDHSRVEPVG HADTGLENIP SFSLDDMVKL VRVPNDGGPL
GIHVVPFSAR GGRTLGLLVK RLEKGGKAEQ ENLFHENDCI VRINDGDLRN RRFEQAQHMF
RQAMCTPIIW FHVVPAANKE QYEQLSQSEK NNYYSSRFSP DSQYIDNRSM HSAGLSALQR
APRPNPPPEP IDSHPRLLPQ STHPSGKPPS APAPAPQNVF STNVSSGYNT KKIGKRLNIQ
LKKGTEGLGF SITSRDVTIG ASAPIYVKNI LPRGAAIQDG RLKAGDRLIE VNGVDLAGKS
QEEVVSLLRS TKMEGTVSLL VFRQEDAFHP RELKAEDEDI VLTPDGTREF LTFEVPLNDS
GSAGLGVSVK GNRSKENHAD LGIFVKSIIN GGAASKDGRL RVNDQLIAVN GESLLGKTNQ
DAMETLRRSM STEGNKRGMI QLIVARRISK CNELKSPGSP SGPELPIETV LDDRERRISH
SLYSGIEGLD ESPTRNAALS RIMGKYQLSP TVNMPQDDTV IIEDDRLPVL PPHLSDQSSS
SSHDDVGFVT TDAGTWAKAA VSDSADCSLS PDVDPVLAFQ REGFGRQSMS EKRTKQFSDA
SQLDFVKTRK SKSMDLGSSP SRDVGPSLGL KKSSSLESLQ TAVAEVTLNG DIPFHRPRPR
IIRGRGCNES FRAAIDKSYD KPVVDDDDEG METLEEDTEE SSRSGRESVS TASDQPSHSL
ERHMNGNQEK GDKMDRRKDK AGKDKKKDRD KEKDKMKAKK GMLKGLGDMF RIQAKTREFR
ERQARERDYA EIQDFHRTLG CNDELMYGGM SSYEASMALN VRPQSPREGD MMDALYAQVK
KPRHSKPSSV DSNRSTPSNH DRIQRLRQEF QQAKQDEDVE DRRRTYSFEQ PWPNSRAAAQ
SGRHSVSVEV QMQRQRQEER EGFQQAQRQY SSLPRQSRKN ASSVSQDSWE QNYSPGEGFQ
SAKENPRYSS YQGSRNGYLG GHGFNARVML ETQELLRQEQ RRKEQQMKKQ PPPPEGLNNY
DSYKKVQDPS YTPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GKPFYS
//
