ID A0A2Y9KFJ6_ENHLU Unreviewed; 1315 AA.
AC A0A2Y9KFJ6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=C-Jun-amino-terminal kinase-interacting protein 3 isoform X7 {ECO:0000313|RefSeq:XP_022372286.1};
GN Name=LOC111156025 {ECO:0000313|RefSeq:XP_022372286.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022372286.1};
RN [1] {ECO:0000313|RefSeq:XP_022372286.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022372286.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
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DR RefSeq; XP_022372286.1; XM_022516578.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.1770; -; 1.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039911; JIP3/JIP4.
DR InterPro; IPR032486; JIP_LZII.
DR InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR034743; RH1.
DR InterPro; IPR034744; RH2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13886:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR Pfam; PF16471; JIP_LZII; 1.
DR Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51776; RH1; 1.
DR PROSITE; PS51777; RH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|RefSeq:XP_022372286.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transferase {ECO:0000313|RefSeq:XP_022372286.1}.
FT DOMAIN 12..100
FT /note="RH1"
FT /evidence="ECO:0000259|PROSITE:PS51776"
FT DOMAIN 500..574
FT /note="RH2"
FT /evidence="ECO:0000259|PROSITE:PS51777"
FT REGION 183..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 437..528
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 246..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..745
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1315 AA; 144742 MW; B68ABCAF6A5A4FEF CRC64;
MMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE VVKELMPLVV
NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL RKQAEEKFIE FEDALEQEKK
ELQTQVEHYE FQTRQLELKA KNYADQISRL EERESEMKKE YNALHQRHTE MIQTYVEHIE
RSKMQQVGGN SQTEGSLPGR SRKERPTSLN VFPLADGMVR AQMGGKLVPA GDHWHLSDLG
QFSSSYQCPQ DDMSESGQSS AAATPSTTGT KSNTPTSSVP SAAVTPLNES LQPLGDYGAG
TKGSKRAREK RNSRNMEVQV TQEMRNVSIG MGSSDEWSDV QDIIESTPEL DMSREPRLDR
MGNSPTQGIV NKAFGINTDS LYHELSTAGS EVIGDVDEGA DLLGMGKEVG NLLLENSQLL
ETKNALNVVK NDLIAKVDQL SGEQEVLKGD LEAARQAKLR LEGRVKDLEE ELRRVKSEAI
VARREPKEEV EDDKVPLAQR RRFTRVEMAR VLMERNQYKE RLMELQEAVR WTEMIRASRE
HPSVQEKKKS TIWQFFSRLF SSSSSPPPAK RPYPSVNIHY KSPTTAGFSQ RRGHAMCPMS
AGSRPLEFFP DDDCTSSARR EQKREQYRQV REHVRNDDGR LQACGWSLPA KYKQLSPNGG
QEDTRMKNVP VPVYCRPLVE KDPTMKLWCA AGVNLSGWKP GEDDSGNGVK PVPGRDPLTC
DREVEGETKS DHTSPEKKAK ELPEPDAASS RVWILTSTLT TSKVVIIDAN QPGTVVDQFT
VCNAHVLCIS SIPAASDSDY PPGEIFLDGD VNPEDSSADG VLAGITLVGC ATRCNVPRSN
CSSRGDTPVL DKGQGEVATV ANGKVNPSQS TEEATEATEV PDSGPSEAEA AAVRPGPLTE
HVFTDLAPSP APTAQPGSEN GPEADTGGAQ PEPEPSADPA GASSSAAPTM WLGAQNGWLY
VHSAVANWKK CLHSIKLKDS VLSLVHVKGR VLVALADGTL AIFHRGEDGQ WDLSNYHLMD
LGHPHHSIRC MAVVCDRVWC GYKNKVHVIQ PKTMQIEKSF DAHPRRESQV RQLAWIGDGV
WVSIRLDSTL RLYHAHTHQH LQDVDIEPYV SKMLGTGKLG FSFVRITALL IAGNRLWVGT
GNGVVISIPL TETVVLHRGQ LLGLRANKTS PTAGEGARPG GVIHVYGDDS CDKSASSFIP
YCSMAQAQLC FHGHRDAVKF FVSVPGNVLA TLNGSVLDSP SESPGPAAPA SDAEGQKLKN
VLVLSGGEGY IDFRIGDGED DDTEENNGDM SQVKPLLSKA ERSHIIVWQV SYSPE
//
