ID A0A2Y9KIA3_ENHLU Unreviewed; 1178 AA.
AC A0A2Y9KIA3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Ataxin-2 isoform X3 {ECO:0000313|RefSeq:XP_022372833.1};
GN Name=LOC111156347 {ECO:0000313|RefSeq:XP_022372833.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022372833.1};
RN [1] {ECO:0000313|RefSeq:XP_022372833.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022372833.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ataxin-2 family.
CC {ECO:0000256|ARBA:ARBA00007503}.
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DR RefSeq; XP_022372833.1; XM_022517125.1.
DR AlphaFoldDB; A0A2Y9KIA3; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd00600; Sm_like; 1.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR045117; ATXN2-like.
DR InterPro; IPR009604; LsmAD_domain.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR025852; SM_dom_ATX.
DR PANTHER; PTHR12854; ATAXIN 2-RELATED; 1.
DR PANTHER; PTHR12854:SF11; ATAXIN-2; 1.
DR Pfam; PF06741; LsmAD; 1.
DR Pfam; PF07145; PAM2; 1.
DR Pfam; PF14438; SM-ATX; 1.
DR SMART; SM01272; LsmAD; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR PROSITE; PS52002; SM; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 102..179
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..437
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 126797 MW; 03AE9356BB09D86D CRC64;
MSLKPQQQQQ QQQQQQPQQQ QQPQQPPPPA AANARKPGGS GGLLTSPAAA PSPSSVSSSS
AVASSSAAAS AGGGRPGLGR GRNSKGLPQS TISFDGIYAN MRMVHILTSV VGSKCEVQVK
NGGIYEGVFK TYSPKCDLVL DAAHEKSMES SSGPKREEIM ESILFKCSDF VVVQFKDMDS
SYARRDAFTD SAISAKVNGE HKEKDLEPWD AGELTTTEEL EALENDVSNG WDPNDMFRYN
EENYGVVSTY DSSLSSYTVP LERDNSEEFL KREARANQLA EEIESSAQYK ARVALENDDR
SEEEKYTAVQ RNSSEREGHS INTRENKYIP PGQRNREVIS WGSGRQNSPC MGQPGSGSMP
SRSTSHTSDF NPNSGSDQRV VNGGVPWPSP CPSPSSRPPS RYQSGPNSLP PRAATPTRPP
SRPPSRPSRP PSHPSAHGSP APVSTMPKRM SSEGPPRMSP KAQRHPRNHR VSAGRGSISS
GLEFVSHTPP SEAAAPPAAR TSPAGGTWSS VVSGVPRLSP KTHRPRSPRQ NSIGNTPGGP
VLASPQAGII PAEAVAMPVP AASPTPASPA SNRAVTPSIE AKDSRLQDQR QNSPAGNKEN
VKPNETSPSF SKTENKGISP IVSEHRKQID DLKKFKNDFR LQPSSTSESM DQLINKNREG
EKSRDLIKDK IEPNAKDSFI ENSSSNCTSS SSKPNSPSIS PSILSNTEHK RGPEVTSQGV
QTSSPGCKQE KDDKEEKKDA AEQVRKSTLN PNAKEFNPRS FSQPKPSTTP TSPRPQAQPS
PSMVGHQQPA PVYTQPVCFA PNMMYPVPVS PGVQPLYPIP MTPMPVNQAK TYRAGKVPNM
PQQRQDQHHQ STMMHPASAA GPPIVATPPA YSTQYVAYSP QQFPNQPLVQ HVPHYQSQHP
HVYSPVIQGN ARMMAPPAHA QPGLVSSSAT QYGAHEQTHA MYVSTGSLAQ QYAHPNATLH
PHTPHPQPSA TPTGQQQSQH GGSHPAPSPV QHHQHQAAQA LHLASPQQQS AIYHAGLAPT
PPSMTPASNT QSPQNSFPTA QQTVFTIHPS HVQPAYTNPP HMAHVPQAHV QSGMVPSHPT
AHAPMMLMTT QPPGGPQAAL AQSALQPIPV STTAHFPYMT HPSGEACVCR GRRAPQSILL
AQIERQAGPA LQAPHSRTRK TRQSVHSRDC DDKFSVRA
//
