GenomeNet

Database: UniProt
Entry: A0A2Y9KIL8_ENHLU
LinkDB: A0A2Y9KIL8_ENHLU
Original site: A0A2Y9KIL8_ENHLU 
ID   A0A2Y9KIL8_ENHLU        Unreviewed;       763 AA.
AC   A0A2Y9KIL8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=enoyl-CoA hydratase {ECO:0000256|ARBA:ARBA00012076};
DE            EC=4.2.1.17 {ECO:0000256|ARBA:ARBA00012076};
GN   Name=LOC111154088 {ECO:0000313|RefSeq:XP_022369165.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022369165.1};
RN   [1] {ECO:0000313|RefSeq:XP_022369165.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022369165.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:31187, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:62548, ChEBI:CHEBI:62616;
CC         Evidence={ECO:0000256|ARBA:ARBA00001391};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31188;
CC         Evidence={ECO:0000256|ARBA:ARBA00001391};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA
CC         + H(+) + NADH; Xref=Rhea:RHEA:31159, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57349, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:62613; Evidence={ECO:0000256|ARBA:ARBA00000193};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31160;
CC         Evidence={ECO:0000256|ARBA:ARBA00000193};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:31163, ChEBI:CHEBI:15377, ChEBI:CHEBI:61526,
CC         ChEBI:CHEBI:62613; Evidence={ECO:0000256|ARBA:ARBA00000469};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:31165;
CC         Evidence={ECO:0000256|ARBA:ARBA00000469};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC   -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022369165.1; XM_022513457.1.
DR   AlphaFoldDB; A0A2Y9KIL8; -.
DR   STRING; 391180.A0A2Y9KIL8; -.
DR   KEGG; elk:111154088; -.
DR   OrthoDB; 622692at2759; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016507; C:mitochondrial fatty acid beta-oxidation multienzyme complex; IEA:InterPro.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR012803; Fa_ox_alpha_mit.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR02441; fa_ox_alpha_mit; 1.
DR   PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          364..541
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          544..639
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          676..752
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   ACT_SITE        510
FT                   /note="For hydroxyacyl-coenzyme A dehydrogenase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR612803-1"
FT   SITE            151
FT                   /note="Important for long-chain enoyl-CoA hydratase
FT                   activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR612803-2"
FT   SITE            173
FT                   /note="Important for long-chain enoyl-CoA hydratase
FT                   activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR612803-2"
FT   SITE            498
FT                   /note="Important for hydroxyacyl-coenzyme A dehydrogenase
FT                   activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR612803-2"
SQ   SEQUENCE   763 AA;  82975 MW;  83E01646C0D0B0BE CRC64;
     MVASRAIGSL SRATASRMLR CSGYICRNFS GSSALRTRTH INYGVKGDVA VVRINSPNSK
     VNTLNKELQS EFMEVMNEIW ASDQVRSAVL ISSKPGCFIA GADINMLASC KTSEEVTQIS
     REGQRTFEKL EKSTKPIVAA ISGACLGGGL ELAISCQYRI ATKDRKTVLG TPEVLLGILP
     GAGGTQRLPK MVGVPAAFDM MLTGRNIHAD RAKKMGLVDQ LVDPLGPGLK PPEERTIEYL
     EEVAVTFAKG LSDKKISIKR DKGLVDKLIS YAMSIPFVRQ QIYKKVEEKV RKQTKGLYPA
     PLKIIDVVKT GIEQGNEAGY LSESQKFGEL AMTRESKALV GLYHGQVLCK KNKFGAPQKE
     AKHLAILGAG LMGAGIAQVS VDKGLRTILK DATLAGLGRG QQQVFKGLND KVKKKALTSF
     ERDSIFSNLV GQLDYQGFEK ADMVIEAVFE DLSLKHRVLK EVEAVIPDHC VFASNTSALP
     INEIAAVSKR PEKVIGMHYF SPVDKMQLLE IITTDKTSKD TTASAVAVGL KQGKVIIVVK
     DGPGFYTTRC LAPMMSEVLR ILQEGVEPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVS
     EDLNKAFGER FGGGSVELLK QMVSRGFLGR KSGKGFYIYQ EGVKNKNVNS DMDGILASLK
     VPPKSEVSSD EDIHYRLVTR FVNEAVMCLQ EGILATPTEG DIGAVFGLGF PPCLGGPFRF
     VDLYGAQKVV DQLRRYEAAY GKPFTPCQLL IDHANSPNKK FYQ
//
DBGET integrated database retrieval system