UniProt: A0A2Y9KIU7

Database: UniProt
Entry: A0A2Y9KIU7_ENHLU

LinkDB:  A0A2Y9KIU7_ENHLU 
Original site:  A0A2Y9KIU7_ENHLU

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Ontology (6)   
   GO (6)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (13)   
   InterPro (8)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (21)   

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ID   A0A2Y9KIU7_ENHLU        Unreviewed;      1176 AA.
AC   A0A2Y9KIU7;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN   Name=LOC111154128 {ECO:0000313|RefSeq:XP_022369240.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022369240.1};
RN   [1] {ECO:0000313|RefSeq:XP_022369240.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022369240.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC       required for retrograde ciliary transport and entry into cilia of G
CC       protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC       ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR   RefSeq; XP_022369240.1; XM_022513532.1.
DR   AlphaFoldDB; A0A2Y9KIU7; -.
DR   KEGG; elk:111154128; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.470; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039857; Ift122/121.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR017233; WDR35.
DR   PANTHER; PTHR12764:SF5; LD29485P; 1.
DR   PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW   Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW   Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW   Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          67..98
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          130..194
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
SQ   SEQUENCE   1176 AA;  133159 MW;  4618BAF628E71D2B CRC64;
     MFFYLSKKIA IPNNVKLKCV SWNKDQGFIA CGGEDGLLKV LKLETQTDDA KLRGLAAPSN
     LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD QNGLIIVWML YKGSWYEEMI NNRNKSVVRS
     MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLC HVAWSADSKI LLFGMANGEI
     HIYDNQGNFI MKMKLNCLVN VTGAISIAGI HWYHGTEGYV EPDCPCLAIC FDNGRCQIMR
     HENDQNPVLI DTGMYVVSIQ WNHMGSVLAV AGSQKVVTQD KDVNTVQFYT PFGEHLGTLK
     VPGKQMSALS WEGGGLKIAL AVDSFIYFAN IRPDYKWGYC SNTVVYAYTR PDRPEYCVIF
     WDTKNNEKYV KYVKSLISIT TCGDFCILAT KADENHPQFV LVLCNSIGTP LDPKYIDIVP
     LFVAMTKTHV IAASKEAFYT WQYRVAKKLT ALEINQITRS RKEGRERIYH VDDTPSGSVD
     GVLDYSKAIQ GTRDPICAIT ASDKTLIVGR ESGTIQRYSL PNVGLIQKYS LNCRAYQLSL
     NCNSSRLAII DISGILTFFD LDARVTDSTG QQVIGELLKL ERKDVWDMKW AKDNPDLFAM
     MEKTRMYVFR NLDPEEPIQT SGYICNFEDL EIKSVLLDEI MKNPEHPNKD YIINFEIRSL
     RDSRALIEKV GIEDASQFIE DNPHPRLWRL LAEAALQKLD LHTAEQAFVR CKDYQGIKFV
     KRLGNLQSES MKQAEVAAYF GRFEEAERMY LEMDRRDLAI GLRLKLGDWF RVLQLLKTGS
     GDADDSLLEQ AHNAIGDYFA DRQKWLNAVQ YYVQGRNQER LAECYYMLED YEGLENLASS
     LPENHKLLPE IAQMFVRVGM CEQAVTAFLK CNQPKAAVDT CVHLNQWNKA VELAKNHSMK
     EIGSLLARYA SHLLEKNKTL DAIELYRKAN YFYDAAKLMF KIADEEAKKR TKPLRVKKLY
     VLSALLIEQY HEQMKNAQRG KVKGKSSEAT SALAGLLEEE ALSTTSRFTD NAWRGAEAYH
     FYILAQRQLY EGYVDTALKT GGHMTEALHL RDYEDIIPAV EIYSLLALCA CASRAFGTCS
     KAFIKLESLE TLSSEQKQQY EDLALEIFTK HTPKDNRKSE LDSLLEGGEG KLPTCVATGS
     PITEYQFWMC SVCKHCVLAQ EISNYNFCPL CHSSVG
//

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