ID A0A2Y9KK45_ENHLU Unreviewed; 596 AA.
AC A0A2Y9KK45;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=ETS-related transcription factor Elf-4 isoform X2 {ECO:0000313|RefSeq:XP_022374252.1};
GN Name=LOC111157264 {ECO:0000313|RefSeq:XP_022374252.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022374252.1};
RN [1] {ECO:0000313|RefSeq:XP_022374252.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022374252.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_022374252.1; XM_022518544.1.
DR AlphaFoldDB; A0A2Y9KK45; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF170; ETS-RELATED TRANSCRIPTION FACTOR ELF-4; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 141..223
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 72..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 63149 MW; FC88A51A6492224A CRC64;
MAQDQILEGS ILLTDDNEAT SQTMSATEVL LNVEAPNDIL DEKQIFSTSE MLPDSDPAPA
ATLPNYLFPV SEPDALSGAG DTDDQEGHCL EEKVPREESA KKTGKSKKRI RKTKGNRSTS
PVTDPSIPIR KKSKDGKGST IYLWEFLLAL LQDRNTCPKY IKWTQREKGI FKLVDSKAVS
KLWGKQKNKP DMNYETMGRA LRYYYQRGIL AKVEGQRLVY QFKEMPKDLV VIEDDEERTE
VMAASPQAST PSTSSTSTTR RASSRVSARA APQGKGGPSW EKPKVQNVGL PPSANLELGL
STDEEIPTTS TVLASLPESQ ARLTKAVSAS SVPGNIHLGV APVGSGSALT LQTIPLTTVL
TSGPPASAAS TQLVLQSVPP ASTFKDTFTL QASFPLNTSF QESQVAAPGA PLILSGLPQL
LAGANLPTNP VPSSVAGAGP AGPSPQPPGT VIAAFIRTSG ATAASGVKEG PLRPSSYVQG
MVTGAPMEGL LVPEETLREL LRDRAHLQPL PTQVVSRGSH NPSLLGNQTF SSPSRPTVGL
TPVAELELSS GSGSGSLFMA EPSVTTSGNL LTRSPTPAPF SPFNPTSLIK MEPHDI
//
