ID A0A2Y9KL14_ENHLU Unreviewed; 1841 AA.
AC A0A2Y9KL14;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Plexin-B2 isoform X1 {ECO:0000313|RefSeq:XP_022374602.1, ECO:0000313|RefSeq:XP_022374603.1};
GN Name=LOC111157476 {ECO:0000313|RefSeq:XP_022374602.1,
GN ECO:0000313|RefSeq:XP_022374603.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022374602.1};
RN [1] {ECO:0000313|RefSeq:XP_022374602.1, ECO:0000313|RefSeq:XP_022374603.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022374602.1,
RC ECO:0000313|RefSeq:XP_022374603.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022374602.1; XM_022518894.1.
DR RefSeq; XP_022374603.1; XM_022518895.1.
DR STRING; 391180.A0A2Y9KL14; -.
DR KEGG; elk:111157476; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd12792; RasGAP_plexin_B2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF9; PLEXIN-B2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1841
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041126863"
FT DOMAIN 1..468
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1841 AA; 205211 MW; A5608C55ECE4C0E0 CRC64;
MALQLWALTL LGLVGTGVGL RPRRLDVFRS DTELNHLVVD EASGVLYAGA VNALYQLSAD
LQLRQQATTG PALDNKKCTP PIEPSQCHEA VQTDNVNQLL LLDPPGNRLV ECGSLFKGIC
ALRALSNIST RLFYEDGSGE KSFVASNDES VATVGLVSAT SPGGERVLFV GKGNGPHDNG
IIVSTRLLDR AEGREAFEAY TDHATYKAGY LSTNTQQFVA AFEDGLYVFF VFNQQDKHPP
RNRTLLARMC KQDPFYYSYL EMDLECLDPS EPQTPAFGTC LAASVAGLSA SRVLYAVFSR
DGRSGGGPRA GLCLFPLDEV HAKMEASRNA CYTGTRDVGR DTFYKPFHGE IQCGGHGPAA
SESFPCGSEH LPYPLGSRDG LTATAVLHRR GLNLTAVVVT AEHGHTVAFL GTSDGRVLKV
YLAPDGSSAE YGSILVEINK RIKRDLVLSP DLAFLYTMTQ DKVFRFPVQD CLSYPTCEQC
HSSQDPYCGW CVIEGRCTRR AECSRAEESG HWLWSRDESC VAITGAQPQN MSRRAQGEVQ
LTVSPLPTLS EEDELLCLFG DSPAHPARVE GDAVICNSPH AIPDTPPGQD HVAVNIQLLF
RHGSVFLTSH LYPFYDCREA MSLAQNLPCI SCASNRWTCQ WDLRYHECRE ASPNPEEGIV
RAHMEDNCPQ FLNPSPLVIP MNHETDVTFQ GKNLDTVKGS SLYVGSDLLK FEEPVSTQEP
GTFFFRTPKL SHDANETLPL HLYVKSYGKN VDSKLQVTLY SCSFGRSDCS LCLAADPAYK
CVWCVEQGRC VYEGLCSNST SECPPPVITR IHPETGPLGG GIRVTILGSN LGVRAEDVKR
VSVAGRNCVF EPERYSVSTR IVCAVEAAPE PITGGVVVNV SGKLGHSPAH VQFTYQQPQP
LSVEPKQGPQ AGGTTLTISG THLDTGSAED VRVTLNDVPC KVTQFGAQLQ CVTGPQPVLG
ELPLEVYYGG SRVSSPAVVF TYRENPVLRA FEPLRSFVSG GRSINVTGQG FSLVQRFAMV
VIAEPLQSWR RRREAGPLQP VTVVGTEYTF YNDSKVVFSS PAVPEEPEAY NLTALIQMDG
HRALLRTEAG AFEYVADPTF ENFTGGVKKQ VNKLIHARGT NLNKAMTLHE AEAFVGAERC
VMKTLTETDL YCEPPEVQPP PKRRQKRDTT HNLPEFIVKF GSREWVLGRV EYDTRVSDVP
LSLILPLVIV PMVAVIAVSV YCYWRKSQQA EREYEKIKSQ LEGLEESVRD RCKKEFTDLM
IEMEDQTNDI HEAGIPVLDY KTYTDRVFFL PSKDGDKDVM ITGRLDIPES RRPVVEQALY
QFSNLLNSKS FLVTFIHTLE SQREFSARAK VYFASLLTVA LHGKLEYYTD IMRTLFLELM
EQYVVAKNPK LMLRRSETVV ERMLSNWMSI CLYQYLKDSA GEPLYKLFKA IKHQVEKGPV
DAVQKKAKYT LNDTGLLGDD VEYAPLTVSV IVQDEGADAV PVKVLNCDTI SQVKEKIIDQ
VYRARPCSRW PRADSVVLEW RPGSTAQILS DLDLTSQREG RWKRINTLMH YNVRDGATLI
LSTVGVSQQP EDSQPDLPGE RHALLEEENR VWHLVRPTDE VEEGRSKRGS VKEKERTKAI
TEIYLTRLLS VKGTLQQFVD NFFQSVLAPG LAVPPAVKYF FDFLDEQAER HDIKDEDTVH
IWKTNSLPLR FWVNVLKNPH FVFDVHVHEV VDASLSVIAQ TFMDACTRTE HKLSRDSPSN
KLLYAKEIST YKKMVEDYYK GIRQMVQVSD QDMNTHLAEI SRAHTDSLNT LVALHQLYQY
TQKYYDEIIN ALEEDPAAQK MQLAFRLQQI AAALENKVTD L
//
