ID A0A2Y9KL89_ENHLU Unreviewed; 640 AA.
AC A0A2Y9KL89;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Eukaryotic peptide chain release factor GTP-binding subunit {ECO:0000256|ARBA:ARBA00015765};
DE AltName: Full=ERF2 {ECO:0000256|ARBA:ARBA00030845};
DE AltName: Full=Polypeptide release factor 3 {ECO:0000256|ARBA:ARBA00029585};
DE AltName: Full=Translation release factor 3 {ECO:0000256|ARBA:ARBA00030210};
GN Name=LOC111155984 {ECO:0000313|RefSeq:XP_022372194.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022372194.1};
RN [1] {ECO:0000313|RefSeq:XP_022372194.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022372194.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR RefSeq; XP_022372194.1; XM_022516486.1.
DR AlphaFoldDB; A0A2Y9KL89; -.
DR KEGG; elk:111155984; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03704; eRF3_C_III; 1.
DR CDD; cd04089; eRF3_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF36; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR Pfam; PF07145; PAM2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 213..439
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 69119 MW; F3B816F7FDE91A54 CRC64;
MDPGSGGGGG GGGGSSSGSS SSDSAPDCWD QADMEAPGPG PCGGAGGPLA TAATEAQREH
LSAAFSRQLN VNAKPFVPNV HAAEFVPSFL RGPAQQPPPP AGAAAAPNHG AGSGAGGPPA
PVEPSQEEQS LLCEGSNSAV SMELSEPVVE NGETEMSPEE SWEHKEEISE AELGGGSLGD
GRPPEEGTQE MMEEEEEIPK PKSVVAPPGA PKKEHVNVVF IGHVDAGKST IGGQIMYLTG
MVDKRTLEKY EREAKEKNRE TWYLSWALDT NQEERDKGKT VEVGRAYFET EKKHFTILDA
PGHKSFVPNM IGGASQADLA VLVISARKGE FETGFEKGGQ TREHAMLAKT AGVKHLIVLI
NKMDDPTVNW SNERYEECKE KLVPFLKKVG FNPKKDIHFM PCSGLTGANL KEQSDFCPWY
TGLPFIPYLD NLPNFNRSVD GPIRLPIVDK YKDMGTVVLG KLESGSICKG QQLVMMPNKH
NVEVLGILSD DVETDSVAPG ENLKIRLKGI EEEEILPGFI LCDLNNLCHS GRTFDAQIVI
IEHKSIICPG YNAVLHIHTC IEEVEITALI CLVDKKSGEK SKTRPRFVKQ DQVCIARLRT
AGTICLETFK DFPQMGRFTL RDEGKTIAIG KVLKLVPEKD
//
