ID A0A2Y9KLC7_ENHLU Unreviewed; 340 AA.
AC A0A2Y9KLC7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Protein-lysine N-methyltransferase EEF2KMT isoform X1 {ECO:0000313|RefSeq:XP_022372234.1};
GN Name=LOC111156002 {ECO:0000313|RefSeq:XP_022372234.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022372234.1};
RN [1] {ECO:0000313|RefSeq:XP_022372234.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022372234.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. EEF2KMT family. {ECO:0000256|ARBA:ARBA00005511}.
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DR RefSeq; XP_022372234.1; XM_022516526.1.
DR AlphaFoldDB; A0A2Y9KLC7; -.
DR STRING; 391180.A0A2Y9KLC7; -.
DR KEGG; elk:111156002; -.
DR OrthoDB; 49253at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029426; FAM86_N.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF164; PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT; 1.
DR Pfam; PF14904; FAM86; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..99
FT /note="FAM86 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14904"
SQ SEQUENCE 340 AA; 37924 MW; D0367EA5774F503E CRC64;
MAPEESAEAA RLLPSFERRF LAARTLRSFP WQSLEEKLRD SSGPELLLNI LQKTVKHPLC
VKHPPSVKYA RCFLSELIRK HEAVHTEPLD ELYEALAEVL MAEEPTQSHR SYLLPSGDSV
TLSESTAIIS HGTTGLVTWD AALYLAEWAI ENPAAFAHRI VLELGSGAGL TGLAICKTCC
PSTYIFSDCH TCVLEQLRRN ILLNGLSLEP DTTDPARHPE HNAYNSESPR VTVAHLDWDV
VTAPELAAFQ PDVIIAADVL YCPETVLSLV RVLQRLSACL KNQQAPEAYI AFTIRNPETC
QLFTSELGRA GIPWEAVPHH NQKLFPYEEH SDMKILKLML
//
