ID   A0A2Y9KM02_ENHLU        Unreviewed;       373 AA.
AC   A0A2Y9KM02;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Interleukin-3 receptor subunit alpha isoform X2 {ECO:0000313|RefSeq:XP_022374133.1};
GN   Name=LOC111157156 {ECO:0000313|RefSeq:XP_022374133.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022374133.1};
RN   [1] {ECO:0000313|RefSeq:XP_022374133.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022374133.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_022374133.1; XM_022518425.1.
DR   AlphaFoldDB; A0A2Y9KM02; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.3850; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR040907; IL3Ra_N.
DR   InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR   InterPro; IPR015321; TypeI_recpt_CBD.
DR   PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23037:SF35; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF18611; IL3Ra_N; 1.
DR   Pfam; PF09240; IL6Ra-bind; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_022374133.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..373
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015873011"
FT   TRANSMEM        334..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          59..131
FT                   /note="IL-3 receptor alpha chain N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18611"
FT   DOMAIN          144..236
FT                   /note="Type I cytokine receptor cytokine-binding"
FT                   /evidence="ECO:0000259|Pfam:PF09240"
SQ   SEQUENCE   373 AA;  42728 MW;  3FC3262BC8F6C86B CRC64;
     MALLWLAVLL TSASSLPQSQ EGRTEPQCVL RVCPAFCCFR ETRRPDRYGS SGSDRYSPIK
     NLRIEPVERR LTWDLHGNVS EIMCFINSKF ITKAINNNRY CQFHILPSCE VKNFSVSLTK
     GPPFSVGIQY PLQEGNPGAA AQGLDCRVHD VDFLTCSWEV GREAPRDIQY HLYWQDLRTQ
     REYECPNYEM DNRGKLVRCH FNDVSRLPKL LQILVRGTSP GVRIPCSDRT VELSEIEILN
     PPTITAMCNK SSLMMEWEAC SHFNNRFEYE LQLQKGSDPA YTEKLQEKFF ELHNPRNYVA
     RLRAKGFYRK SWSEWSAPQR FACDVGEDSQ RPDWLLSALV LLATLLVLGL VIALCGSVAE
     ALSSHPAHER PHH
//