ID A0A2Y9KM94_ENHLU Unreviewed; 1004 AA.
AC A0A2Y9KM94;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=NLR family CARD domain-containing protein 3 isoform X5 {ECO:0000313|RefSeq:XP_022372498.1, ECO:0000313|RefSeq:XP_022372499.1};
GN Name=LOC111156134 {ECO:0000313|RefSeq:XP_022372498.1,
GN ECO:0000313|RefSeq:XP_022372499.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022372499.1};
RN [1] {ECO:0000313|RefSeq:XP_022372498.1, ECO:0000313|RefSeq:XP_022372499.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022372498.1,
RC ECO:0000313|RefSeq:XP_022372499.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022372498.1; XM_022516790.1.
DR RefSeq; XP_022372499.1; XM_022516791.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF13516; LRR_6; 7.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 140..271
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 108675 MW; FD8CB20192568456 CRC64;
MRKQEVRTSG EAGQGQGPGP PAGQVKALVD LLAGKSSQGS QAPQTPDRTP HALPFGLCPT
DSRIQKCQET LLNRAKGSPE LGGPSPRLTS LLLVEGLTDL QLKEHDFTQV ETTRGDWHLA
RTIALDRLFL PLSRVSIPPR ISITIGVAGV GKTTLVRNFV HLWAQGQVGK DFSLVLPLTF
RDLNTHEKLS ADRLLRSVFP HTGESGLVAA ALPKILLILD GLDECKTPLD FSNTVACTDP
KKEIQVDHLI TNIIRGNLFP EVSVWVTSRP GMAGQIPGGL VDRMTEIRGF TEEEIKECLE
ELFPEDHTLS DWVLRQVQAD RALYLMCTVP AFCRLAGLAL GHLSRSKPGP HDAEPWTPRT
LCELYSWYFR MALGGDGQEK GKASPRIEQV AHSSRKMVGT LGRLAFHGLV RRKYVFYEQD
LKAFGVDLAL LQSALCGCFL RREETLASAA AYCFAHLSLQ EFVAAAYYYS ASRRAIFDLF
TEGGVSWPRL GFLTHFRGAA QRALQAEDGR LDVFLRFLSG LLSPRVNALL AGSLLAQGEH
QAYRAQVAEL LQGCLRPNVA VSARAVNVLR CLRELQHPEP ARGVEEALQS GALAGLSSPQ
HHAALAYLLQ VSDAYAQEAN LSLCLSGGVL RSLLPQLLYC RSLRLDSNQF QDPVMELLGS
VLSGKDCRIQ KISLAENQIS NKGAKALARS LLVNRSLTSL DLRNNSIGPQ GAKALADALK
INRTLAFLSL QSNAIRDNGA RSVAEALAAN RTLSVLHLQK NTIGPVGAQQ MADTLKQNRS
LKELIFSSNS IGDGGAEALA KALKVNQGLE SLDLQSNSIS DVGVAALMEA LCANQTLVSL
NLRENSISSE GARELARALS INTTLKNLEY PDSQPPPRPG RPGHRGGDER KPGPQVPSPA
VELHSGRCCQ GPGTSTTAQQ EPDQPRFTGE RHRGRRRLCS GQCPQGQHGP HCALSAGGLH
WLPGGPGARG RPGREQNLGD SRLTRKRHWG GGGQSLGKCS EGEL
//
