ID   A0A2Y9KMW9_ENHLU        Unreviewed;       517 AA.
AC   A0A2Y9KMW9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Keratin, type II cytoskeletal 78 {ECO:0000313|RefSeq:XP_022375272.1};
GN   Name=LOC111157865 {ECO:0000313|RefSeq:XP_022375272.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022375272.1};
RN   [1] {ECO:0000313|RefSeq:XP_022375272.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022375272.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_022375272.1; XM_022519564.1.
DR   AlphaFoldDB; A0A2Y9KMW9; -.
DR   STRING; 391180.A0A2Y9KMW9; -.
DR   KEGG; elk:111157865; -.
DR   OrthoDB; 4640531at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF18; KERATIN, TYPE II CYTOSKELETAL 78; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          106..419
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          43..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          161..209
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          317..397
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   517 AA;  56516 MW;  230210F5A92FAABF CRC64;
     MSRSSCQAWR GFGARSACSA PPGGRGGRSS FSSRSLISFR GCRGASSGRA WGSGGGPGVR
     FGEGRGGPRL SLCPPGDIQE VTINSSLLTP LKMEIDPQFQ VVRTQETQEI RTLNNQFASF
     IDKVRFLEQQ NKVLETKWEL LQRLGVSDSP PDLESFFEGY LARLRWQLEQ LQRERRAVDA
     ELKSCQDQEE EYKAKYEEES RKHATAENDF VVLKKDVDGV FLNKMELEGK LASLREYLCF
     LRQLNEEELG QLQTQASDMS VVLSMDNNRV LDFSDIIAEV RARYEEIAQS SKAEVEMLYQ
     TKYQELQASA RLHGDSMKET KVQISQLQQA SKSLQSQIEN LKKQNADLQA TIANAEQRGE
     LALKDAQTKL DELEAALRAA KQDLARVLRE YQELMSTKLA LDVEIATYRR LLEVEESRMS
     GRCTSQATIS VGGGSVVVSG GAGSGLGATC GLADEKGSFG SSCSSIVTGG SNVILGSGQG
     PIWGSCSVSG SSSGSSSGGH TILKKTVESS LKMSVTY
//