ID A0A2Y9KNR3_ENHLU Unreviewed; 861 AA.
AC A0A2Y9KNR3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Rho GTPase-activating protein 27 isoform X1 {ECO:0000313|RefSeq:XP_022375612.1, ECO:0000313|RefSeq:XP_022375613.1};
GN Name=LOC111158080 {ECO:0000313|RefSeq:XP_022375612.1,
GN ECO:0000313|RefSeq:XP_022375613.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022375612.1};
RN [1] {ECO:0000313|RefSeq:XP_022375612.1, ECO:0000313|RefSeq:XP_022375613.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022375612.1,
RC ECO:0000313|RefSeq:XP_022375613.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022375612.1; XM_022519904.1.
DR RefSeq; XP_022375613.1; XM_022519905.1.
DR STRING; 391180.A0A2Y9KNR3; -.
DR KEGG; elk:111158080; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12069; SH3_ARHGAP27; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF104; RHO GTPASE-ACTIVATING PROTEIN 27; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 3.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 246..280
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 299..333
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 417..444
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 474..590
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 669..858
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 122..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..341
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 95951 MW; 328950BF8FA1E4A7 CRC64;
MAADVEGDVY VLVEHPFEYT GKDGRRVAIQ PNERYRLLRR STEHWWHVRR EPGGRPFYLP
AQYVRELPAL GDPATASPPP ALRPGPAAPE PLAYDYRFVS APAPAGPDGT TTKPRGRVSS
LCGPARRGAA TPRSSPAPGL PTCLYTRPAA PVRPAQSLDD LARAAVAPPA GLLGSAGSFK
ACSVAGSWVC PRPLARSDSE NVYEAIQDVR GPPREERPPQ VDDPPEPVYE NVERQPSVSS
PGATAGPRPP AWETHTDAGS GRPYYYNPDT GVTTWESPFE AAEGISSPAT SPASVGSRES
LETDWGQYWD EESRRVFFYN PLTGETVWED ETEDEPEDEL EMQPSLSPLS PRDQRPPTPE
TDYPELLTSY PEEDYSPLGS FSEPRSASPL AAPPGWSLRV NPEGQTLYTN NFTQEQWVRL
EDQYGKPYFY NPHDASVQWE LPQVPVPAPR SIHKSSQDSE TPAQASPPEE KTKTLDKAGV
LHRTKTVDKG KRLRKKHWSA SWTVLEGGVL TFFKDSKASA AGGLRQPPKL STPEYTVDLR
GASLSWAPKD KSSRKNVLEL RSRDGSEYLI QHDSEAIIST WHKAIGEGIQ ELSADLPPEE
ESESSSADFG SSERLGSLRE EEARPGAGAV IPESDLSRVR QRLRKFLLKR PTLQSLREKG
YIKDQVFGCA LAALCERERS SVPRFVQQCI RTVEARGLDI DGLYRISGNL ATIQKLRYKV
DHDERLDLDD GRWEDVHVIT GALKLFFREL PEPLFPFSHF RQFIAAIKLQ DQAQRSRCVR
DLVRSLPAPN HDTLRLLFQH LCRVIEHGDQ NRMSVQSVAI VFGPTLLRPE TEETSMPMTM
VFQNQVVELI LQRCSDIFQP H
//
